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Function, Evolution, and Composition of the RpoS Regulon in Escherichia coli
For many bacteria, successful growth and survival depends on efficient adaptation to rapidly changing conditions. In Escherichia coli, the RpoS alternative sigma factor plays a central role in the adaptation to many suboptimal growth conditions by controlling the expression of many genes that protec...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527412/ https://www.ncbi.nlm.nih.gov/pubmed/33042067 http://dx.doi.org/10.3389/fmicb.2020.560099 |
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author | Schellhorn, Herb E. |
author_facet | Schellhorn, Herb E. |
author_sort | Schellhorn, Herb E. |
collection | PubMed |
description | For many bacteria, successful growth and survival depends on efficient adaptation to rapidly changing conditions. In Escherichia coli, the RpoS alternative sigma factor plays a central role in the adaptation to many suboptimal growth conditions by controlling the expression of many genes that protect the cell from stress and help the cell scavenge nutrients. Neither RpoS or the genes it controls are essential for growth and, as a result, the composition of the regulon and the nature of RpoS control in E. coli strains can be variable. RpoS controls many genetic systems, including those affecting pathogenesis, phenotypic traits including metabolic pathways and biofilm formation, and the expression of genes needed to survive nutrient deprivation. In this review, I review the origin of RpoS and assess recent transcriptomic and proteomic studies to identify features of the RpoS regulon in specific clades of E. coli to identify core functions of the regulon and to identify more specialized potential roles for the regulon in E. coli subgroups. |
format | Online Article Text |
id | pubmed-7527412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75274122020-10-09 Function, Evolution, and Composition of the RpoS Regulon in Escherichia coli Schellhorn, Herb E. Front Microbiol Microbiology For many bacteria, successful growth and survival depends on efficient adaptation to rapidly changing conditions. In Escherichia coli, the RpoS alternative sigma factor plays a central role in the adaptation to many suboptimal growth conditions by controlling the expression of many genes that protect the cell from stress and help the cell scavenge nutrients. Neither RpoS or the genes it controls are essential for growth and, as a result, the composition of the regulon and the nature of RpoS control in E. coli strains can be variable. RpoS controls many genetic systems, including those affecting pathogenesis, phenotypic traits including metabolic pathways and biofilm formation, and the expression of genes needed to survive nutrient deprivation. In this review, I review the origin of RpoS and assess recent transcriptomic and proteomic studies to identify features of the RpoS regulon in specific clades of E. coli to identify core functions of the regulon and to identify more specialized potential roles for the regulon in E. coli subgroups. Frontiers Media S.A. 2020-09-17 /pmc/articles/PMC7527412/ /pubmed/33042067 http://dx.doi.org/10.3389/fmicb.2020.560099 Text en Copyright © 2020 Schellhorn. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Schellhorn, Herb E. Function, Evolution, and Composition of the RpoS Regulon in Escherichia coli |
title | Function, Evolution, and Composition of the RpoS Regulon in Escherichia coli |
title_full | Function, Evolution, and Composition of the RpoS Regulon in Escherichia coli |
title_fullStr | Function, Evolution, and Composition of the RpoS Regulon in Escherichia coli |
title_full_unstemmed | Function, Evolution, and Composition of the RpoS Regulon in Escherichia coli |
title_short | Function, Evolution, and Composition of the RpoS Regulon in Escherichia coli |
title_sort | function, evolution, and composition of the rpos regulon in escherichia coli |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527412/ https://www.ncbi.nlm.nih.gov/pubmed/33042067 http://dx.doi.org/10.3389/fmicb.2020.560099 |
work_keys_str_mv | AT schellhornherbe functionevolutionandcompositionoftherposreguloninescherichiacoli |