A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration

Wound healing and tissue regeneration is an intricate biological process that involves repair of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing and tissue regeneration highly overlap with cancer causing pathways. Usually, subsequent tissue damage events inclu...

Descripción completa

Detalles Bibliográficos
Autores principales: Arshad, Tanzeela, Mansur, Fizzah, Palek, Richard, Manzoor, Sobia, Liska, Vaclav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527413/
https://www.ncbi.nlm.nih.gov/pubmed/33042126
http://dx.doi.org/10.3389/fimmu.2020.02148
_version_ 1783589050280574976
author Arshad, Tanzeela
Mansur, Fizzah
Palek, Richard
Manzoor, Sobia
Liska, Vaclav
author_facet Arshad, Tanzeela
Mansur, Fizzah
Palek, Richard
Manzoor, Sobia
Liska, Vaclav
author_sort Arshad, Tanzeela
collection PubMed
description Wound healing and tissue regeneration is an intricate biological process that involves repair of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing and tissue regeneration highly overlap with cancer causing pathways. Usually, subsequent tissue damage events include release of a number of cytokines to accomplish post-trauma restoration. IL-22 is one of the cytokines that are immediately produced to initiate immune response against several tissue impairments. IL-22 is a fundamental mediator in inflammation, mucous production, protective role against pathogens, wound healing, and tissue regeneration. However, accumulating evidence suggests pivotal role of IL-22 in instigation of various cancers due to its pro-inflammatory and tissue repairing activity. In this review, we summarize how healing effects of IL-22, when executed in an uncontrollable fashion can lead to carcinogenesis.
format Online
Article
Text
id pubmed-7527413
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-75274132020-10-09 A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration Arshad, Tanzeela Mansur, Fizzah Palek, Richard Manzoor, Sobia Liska, Vaclav Front Immunol Immunology Wound healing and tissue regeneration is an intricate biological process that involves repair of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing and tissue regeneration highly overlap with cancer causing pathways. Usually, subsequent tissue damage events include release of a number of cytokines to accomplish post-trauma restoration. IL-22 is one of the cytokines that are immediately produced to initiate immune response against several tissue impairments. IL-22 is a fundamental mediator in inflammation, mucous production, protective role against pathogens, wound healing, and tissue regeneration. However, accumulating evidence suggests pivotal role of IL-22 in instigation of various cancers due to its pro-inflammatory and tissue repairing activity. In this review, we summarize how healing effects of IL-22, when executed in an uncontrollable fashion can lead to carcinogenesis. Frontiers Media S.A. 2020-09-17 /pmc/articles/PMC7527413/ /pubmed/33042126 http://dx.doi.org/10.3389/fimmu.2020.02148 Text en Copyright © 2020 Arshad, Mansur, Palek, Manzoor and Liska. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Arshad, Tanzeela
Mansur, Fizzah
Palek, Richard
Manzoor, Sobia
Liska, Vaclav
A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration
title A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration
title_full A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration
title_fullStr A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration
title_full_unstemmed A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration
title_short A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration
title_sort double edged sword role of interleukin-22 in wound healing and tissue regeneration
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527413/
https://www.ncbi.nlm.nih.gov/pubmed/33042126
http://dx.doi.org/10.3389/fimmu.2020.02148
work_keys_str_mv AT arshadtanzeela adoubleedgedswordroleofinterleukin22inwoundhealingandtissueregeneration
AT mansurfizzah adoubleedgedswordroleofinterleukin22inwoundhealingandtissueregeneration
AT palekrichard adoubleedgedswordroleofinterleukin22inwoundhealingandtissueregeneration
AT manzoorsobia adoubleedgedswordroleofinterleukin22inwoundhealingandtissueregeneration
AT liskavaclav adoubleedgedswordroleofinterleukin22inwoundhealingandtissueregeneration
AT arshadtanzeela doubleedgedswordroleofinterleukin22inwoundhealingandtissueregeneration
AT mansurfizzah doubleedgedswordroleofinterleukin22inwoundhealingandtissueregeneration
AT palekrichard doubleedgedswordroleofinterleukin22inwoundhealingandtissueregeneration
AT manzoorsobia doubleedgedswordroleofinterleukin22inwoundhealingandtissueregeneration
AT liskavaclav doubleedgedswordroleofinterleukin22inwoundhealingandtissueregeneration

Ejemplares similares