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Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated
One of the central functions of the liver is excretion of bile into the intestine. Currently, bile excretion is explained by the osmotic model, according to which bile acids are excreted by hepatocytes into the bile canaliculi and since bile acids are osmotically active they draw water into the cana...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Leibniz Research Centre for Working Environment and Human Factors
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527507/ https://www.ncbi.nlm.nih.gov/pubmed/33013271 http://dx.doi.org/10.17179/excli2020-2836 |
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author | Ezzat Ahmed, Ahmed |
author_facet | Ezzat Ahmed, Ahmed |
author_sort | Ezzat Ahmed, Ahmed |
collection | PubMed |
description | One of the central functions of the liver is excretion of bile into the intestine. Currently, bile excretion is explained by the osmotic model, according to which bile acids are excreted by hepatocytes into the bile canaliculi and since bile acids are osmotically active they draw water into the canalicular lumen. Bile canaliculi are closed at the central side. Therefore, bile was postulated to flow to the open side into the ducts. However, bile flow in canaliculi has never been measured because of the small canalicular diameter which does not allow analysis of flux by conventional methods. Recently, methods have been developed that allow flow analysis in bile canaliculi and ducts. Interestingly, no measurable directed flow was observed in the canaliculi. Instead, small molecules in bile canaliculi reached the larger bile ducts by diffusion. Only there measurable flow sets in. The pathophysiological implications of this novel observation are discussed. |
format | Online Article Text |
id | pubmed-7527507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Leibniz Research Centre for Working Environment and Human Factors |
record_format | MEDLINE/PubMed |
spelling | pubmed-75275072020-10-01 Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated Ezzat Ahmed, Ahmed EXCLI J Editorial Material One of the central functions of the liver is excretion of bile into the intestine. Currently, bile excretion is explained by the osmotic model, according to which bile acids are excreted by hepatocytes into the bile canaliculi and since bile acids are osmotically active they draw water into the canalicular lumen. Bile canaliculi are closed at the central side. Therefore, bile was postulated to flow to the open side into the ducts. However, bile flow in canaliculi has never been measured because of the small canalicular diameter which does not allow analysis of flux by conventional methods. Recently, methods have been developed that allow flow analysis in bile canaliculi and ducts. Interestingly, no measurable directed flow was observed in the canaliculi. Instead, small molecules in bile canaliculi reached the larger bile ducts by diffusion. Only there measurable flow sets in. The pathophysiological implications of this novel observation are discussed. Leibniz Research Centre for Working Environment and Human Factors 2020-08-31 /pmc/articles/PMC7527507/ /pubmed/33013271 http://dx.doi.org/10.17179/excli2020-2836 Text en Copyright © 2020 Ezzat Ahmed http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
spellingShingle | Editorial Material Ezzat Ahmed, Ahmed Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated |
title | Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated |
title_full | Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated |
title_fullStr | Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated |
title_full_unstemmed | Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated |
title_short | Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated |
title_sort | highlight report: new insights in liver physiology: canalicular bile flux is diffusion dominated |
topic | Editorial Material |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527507/ https://www.ncbi.nlm.nih.gov/pubmed/33013271 http://dx.doi.org/10.17179/excli2020-2836 |
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