Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review

A 37-year-old man was admitted to our department following the detection of bulky tumors in his bilateral adrenal glands. A biopsy resulted in the diagnosis of extranodal NK/T cell lymphoma, nasal type (ENKL). After debulking by chemotherapy, allogeneic hematopoietic stem cell transplantation (alloH...

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Autores principales: Ichikawa, Satoshi, Saito, Kei, Fukuhara, Noriko, Yokoyama, Hisayuki, Onodera, Koichi, Onishi, Yasushi, Ichinohasama, Ryo, Harigae, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527573/
https://www.ncbi.nlm.nih.gov/pubmed/33024692
http://dx.doi.org/10.1016/j.lrr.2020.100223
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author Ichikawa, Satoshi
Saito, Kei
Fukuhara, Noriko
Yokoyama, Hisayuki
Onodera, Koichi
Onishi, Yasushi
Ichinohasama, Ryo
Harigae, Hideo
author_facet Ichikawa, Satoshi
Saito, Kei
Fukuhara, Noriko
Yokoyama, Hisayuki
Onodera, Koichi
Onishi, Yasushi
Ichinohasama, Ryo
Harigae, Hideo
author_sort Ichikawa, Satoshi
collection PubMed
description A 37-year-old man was admitted to our department following the detection of bulky tumors in his bilateral adrenal glands. A biopsy resulted in the diagnosis of extranodal NK/T cell lymphoma, nasal type (ENKL). After debulking by chemotherapy, allogeneic hematopoietic stem cell transplantation (alloHCT) was performed. Relapses in the liver and adrenal glands were identified 2 months post alloHCT, for which temporary administration of l-asparaginase resulted in complete metabolic response. However, multiple relapses in the central nervous system and lethal lymphomatous meningitis successively developed. Primary adrenal ENKL could tend to present as bulky lesion and follow an aggressive clinical course.
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spelling pubmed-75275732020-10-05 Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review Ichikawa, Satoshi Saito, Kei Fukuhara, Noriko Yokoyama, Hisayuki Onodera, Koichi Onishi, Yasushi Ichinohasama, Ryo Harigae, Hideo Leuk Res Rep Article A 37-year-old man was admitted to our department following the detection of bulky tumors in his bilateral adrenal glands. A biopsy resulted in the diagnosis of extranodal NK/T cell lymphoma, nasal type (ENKL). After debulking by chemotherapy, allogeneic hematopoietic stem cell transplantation (alloHCT) was performed. Relapses in the liver and adrenal glands were identified 2 months post alloHCT, for which temporary administration of l-asparaginase resulted in complete metabolic response. However, multiple relapses in the central nervous system and lethal lymphomatous meningitis successively developed. Primary adrenal ENKL could tend to present as bulky lesion and follow an aggressive clinical course. Elsevier 2020-09-28 /pmc/articles/PMC7527573/ /pubmed/33024692 http://dx.doi.org/10.1016/j.lrr.2020.100223 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Ichikawa, Satoshi
Saito, Kei
Fukuhara, Noriko
Yokoyama, Hisayuki
Onodera, Koichi
Onishi, Yasushi
Ichinohasama, Ryo
Harigae, Hideo
Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review
title Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review
title_full Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review
title_fullStr Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review
title_full_unstemmed Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review
title_short Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review
title_sort primary adrenal extranodal nk/t-cell lymphoma: a case report and literature review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527573/
https://www.ncbi.nlm.nih.gov/pubmed/33024692
http://dx.doi.org/10.1016/j.lrr.2020.100223
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