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Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR

Little is known about what roles the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play in drug metabolism in high-altitude hypoxia. Likewise, the potential interaction of nuclear receptors and drug metabolism enzymes during drug metabolism of high-altitude hypoxia is not full...

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Detalles Bibliográficos
Autores principales:	Duan, Ya-bin, Zhu, Jun-bo, Yang, Jian-xin, Liu, Gui-qin, Bai, Xue, Qu, Ning, Wang, Xue-jun, Li, Xiang-yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527593/ https://www.ncbi.nlm.nih.gov/pubmed/33041817 http://dx.doi.org/10.3389/fphar.2020.574176

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