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Developmental Programming of NAFLD by Parental Obesity

The surge of obesity across generations has become an increasingly relevant issue, with consequences for associated comorbidities in offspring. Data from longitudinal birth cohort studies support an association between maternal obesity and offspring nonalcoholic fatty liver disease (NAFLD), suggesti...

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Autor principal: Thompson, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527686/
https://www.ncbi.nlm.nih.gov/pubmed/33024911
http://dx.doi.org/10.1002/hep4.1578
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author Thompson, Michael D.
author_facet Thompson, Michael D.
author_sort Thompson, Michael D.
collection PubMed
description The surge of obesity across generations has become an increasingly relevant issue, with consequences for associated comorbidities in offspring. Data from longitudinal birth cohort studies support an association between maternal obesity and offspring nonalcoholic fatty liver disease (NAFLD), suggesting that perinatal obesity or obesogenic diet exposure reprograms offspring liver and increases NAFLD susceptibility. In preclinical models, offspring exposed to maternal obesogenic diet have increased hepatic steatosis after diet‐induced obesity; however, the implications for later NAFLD development and progression are still unclear. Although some models show increased NAFLD incidence and progression in offspring, development of nonalcoholic steatohepatitis with fibrosis may be model dependent. Multigenerational programming of NAFLD phenotypes occurs after maternal obesogenic diet exposure; however, the mechanisms for such programming remain poorly understood. Likewise, emerging data on the role of paternal obesity in offspring NAFLD development reveal incomplete mechanisms. This review will explore the impact of parental obesity and obesogenic diet exposure on offspring NAFLD and areas for further investigation, including the impact of parental diet on disease progression, and consider potential interventions in preclinical models.
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spelling pubmed-75276862020-10-05 Developmental Programming of NAFLD by Parental Obesity Thompson, Michael D. Hepatol Commun Review The surge of obesity across generations has become an increasingly relevant issue, with consequences for associated comorbidities in offspring. Data from longitudinal birth cohort studies support an association between maternal obesity and offspring nonalcoholic fatty liver disease (NAFLD), suggesting that perinatal obesity or obesogenic diet exposure reprograms offspring liver and increases NAFLD susceptibility. In preclinical models, offspring exposed to maternal obesogenic diet have increased hepatic steatosis after diet‐induced obesity; however, the implications for later NAFLD development and progression are still unclear. Although some models show increased NAFLD incidence and progression in offspring, development of nonalcoholic steatohepatitis with fibrosis may be model dependent. Multigenerational programming of NAFLD phenotypes occurs after maternal obesogenic diet exposure; however, the mechanisms for such programming remain poorly understood. Likewise, emerging data on the role of paternal obesity in offspring NAFLD development reveal incomplete mechanisms. This review will explore the impact of parental obesity and obesogenic diet exposure on offspring NAFLD and areas for further investigation, including the impact of parental diet on disease progression, and consider potential interventions in preclinical models. John Wiley and Sons Inc. 2020-08-09 /pmc/articles/PMC7527686/ /pubmed/33024911 http://dx.doi.org/10.1002/hep4.1578 Text en © 2020 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of the American Association for the Study of Liver Diseases. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review
Thompson, Michael D.
Developmental Programming of NAFLD by Parental Obesity
title Developmental Programming of NAFLD by Parental Obesity
title_full Developmental Programming of NAFLD by Parental Obesity
title_fullStr Developmental Programming of NAFLD by Parental Obesity
title_full_unstemmed Developmental Programming of NAFLD by Parental Obesity
title_short Developmental Programming of NAFLD by Parental Obesity
title_sort developmental programming of nafld by parental obesity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527686/
https://www.ncbi.nlm.nih.gov/pubmed/33024911
http://dx.doi.org/10.1002/hep4.1578
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