Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family

The potassium channel Kv1.3, involved in several important pathologies, is the target of a family of psoralen-based drugs whose mechanism of action is not fully understood. Here we provide evidence for a physical interaction of the mitochondria-located Kv1.3 (mtKv1.3) and Complex I of the respirator...

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Detalles Bibliográficos
Autores principales: Peruzzo, Roberta, Mattarei, Andrea, Azzolini, Michele, Becker-Flegler, Katrin Anne, Romio, Matteo, Rigoni, Giovanni, Carrer, Andrea, Biasutto, Lucia, Parrasia, Sofia, Kadow, Stephanie, Managò, Antonella, Urbani, Andrea, Rossa, Andrea, Semenzato, Gianpietro, Soriano, Maria Eugenia, Trentin, Livio, Ahmad, Syed, Edwards, Michael, Gulbins, Erich, Paradisi, Cristina, Zoratti, Mario, Leanza, Luigi, Szabò, Ildikò
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527709/
https://www.ncbi.nlm.nih.gov/pubmed/33007503
http://dx.doi.org/10.1016/j.redox.2020.101705

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