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Acid enhancement of ROS generation by complex-I reverse electron transport is balanced by acid inhibition of complex-II: Relevance for tissue reperfusion injury

Generation of mitochondrial reactive oxygen species (ROS) is an important process in triggering cellular necrosis and tissue infarction during ischemia-reperfusion (IR) injury. Ischemia results in accumulation of the metabolite succinate. Rapid oxidation of this succinate by mitochondrial complex II...

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Detalles Bibliográficos
Autores principales:	Milliken, Alexander S., Kulkarni, Chaitanya A., Brookes, Paul S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527751/ https://www.ncbi.nlm.nih.gov/pubmed/33007502 http://dx.doi.org/10.1016/j.redox.2020.101733

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