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Reinventing nano drug delivery systems for hydrophilic active ingredients in Ayurvedic lipid based formulations containing poly herbal decoction
BACKGROUND: Anu Tailam, an Ayurvedic medicated oil where ‘anu’ meant for atom and ‘tailam’ meant for oil and virtually meant for ‘oil of subtle or atomic size particles’. Since the major active ingredients in this formulation are incorporated from the polyherbal decoction, it is expected to contain...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527804/ https://www.ncbi.nlm.nih.gov/pubmed/30635246 http://dx.doi.org/10.1016/j.jaim.2018.01.008 |
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author | Duraipandi, Selvakumar Selvakumar, Vijaya |
author_facet | Duraipandi, Selvakumar Selvakumar, Vijaya |
author_sort | Duraipandi, Selvakumar |
collection | PubMed |
description | BACKGROUND: Anu Tailam, an Ayurvedic medicated oil where ‘anu’ meant for atom and ‘tailam’ meant for oil and virtually meant for ‘oil of subtle or atomic size particles’. Since the major active ingredients in this formulation are incorporated from the polyherbal decoction, it is expected to contain predominantly water soluble ingredients. OBJECTIVES: It is hypothesized that these polar active botanical ingredients are present in the formulation should be either suspended in the form of submicron particles or entrapped in the submicron vesicular structures since the formulation did not show any precipitation or phase separation instead showed a monophasic oily liquid with very little moisture. MATERIALS AND METHODS: In the present investigation, the micro architecture of the anu tailam is studied via column chromatography and high performance thin layer chromatography to prove the contents are polar hydrophilic compounds followed by optical microscopy, photon correlation Spectroscopy (PCS) and environmental scanning electron microscope (ESEM) to study the particle/vesicle size of the formulation. RESULTS: In this study, it was proved that the formulation contained only polar ingredients and can be extracted in polar solvents like methanol and ethanol. It was also found that the formulation taken for study contained nano particles of the active botanical ingredients embedded in a network of vesicular structures of the lipid base. CONCLUSION: The selected Ayurvedic formulation ‘anutailam’ found to contain novel nano drug delivery system to deliver water soluble ingredients across barriers. |
format | Online Article Text |
id | pubmed-7527804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-75278042020-10-05 Reinventing nano drug delivery systems for hydrophilic active ingredients in Ayurvedic lipid based formulations containing poly herbal decoction Duraipandi, Selvakumar Selvakumar, Vijaya J Ayurveda Integr Med Original Research Article (Experimental) BACKGROUND: Anu Tailam, an Ayurvedic medicated oil where ‘anu’ meant for atom and ‘tailam’ meant for oil and virtually meant for ‘oil of subtle or atomic size particles’. Since the major active ingredients in this formulation are incorporated from the polyherbal decoction, it is expected to contain predominantly water soluble ingredients. OBJECTIVES: It is hypothesized that these polar active botanical ingredients are present in the formulation should be either suspended in the form of submicron particles or entrapped in the submicron vesicular structures since the formulation did not show any precipitation or phase separation instead showed a monophasic oily liquid with very little moisture. MATERIALS AND METHODS: In the present investigation, the micro architecture of the anu tailam is studied via column chromatography and high performance thin layer chromatography to prove the contents are polar hydrophilic compounds followed by optical microscopy, photon correlation Spectroscopy (PCS) and environmental scanning electron microscope (ESEM) to study the particle/vesicle size of the formulation. RESULTS: In this study, it was proved that the formulation contained only polar ingredients and can be extracted in polar solvents like methanol and ethanol. It was also found that the formulation taken for study contained nano particles of the active botanical ingredients embedded in a network of vesicular structures of the lipid base. CONCLUSION: The selected Ayurvedic formulation ‘anutailam’ found to contain novel nano drug delivery system to deliver water soluble ingredients across barriers. Elsevier 2020 2019-01-08 /pmc/articles/PMC7527804/ /pubmed/30635246 http://dx.doi.org/10.1016/j.jaim.2018.01.008 Text en © 2018 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Publishing Services by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Article (Experimental) Duraipandi, Selvakumar Selvakumar, Vijaya Reinventing nano drug delivery systems for hydrophilic active ingredients in Ayurvedic lipid based formulations containing poly herbal decoction |
title | Reinventing nano drug delivery systems for hydrophilic active ingredients in Ayurvedic lipid based formulations containing poly herbal decoction |
title_full | Reinventing nano drug delivery systems for hydrophilic active ingredients in Ayurvedic lipid based formulations containing poly herbal decoction |
title_fullStr | Reinventing nano drug delivery systems for hydrophilic active ingredients in Ayurvedic lipid based formulations containing poly herbal decoction |
title_full_unstemmed | Reinventing nano drug delivery systems for hydrophilic active ingredients in Ayurvedic lipid based formulations containing poly herbal decoction |
title_short | Reinventing nano drug delivery systems for hydrophilic active ingredients in Ayurvedic lipid based formulations containing poly herbal decoction |
title_sort | reinventing nano drug delivery systems for hydrophilic active ingredients in ayurvedic lipid based formulations containing poly herbal decoction |
topic | Original Research Article (Experimental) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527804/ https://www.ncbi.nlm.nih.gov/pubmed/30635246 http://dx.doi.org/10.1016/j.jaim.2018.01.008 |
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