Cargando…

Prakriti phenotypes as a stratifier of gut microbiome: A new frontier in personalized medicine?

Ayurveda has a rich history and its significance woven deeply in the Indian culture. The concept of prakriti (a person’s “nature” or constitutional type determined by the proportion of three doshas, namely - vata, pitta and kapha) in Ayurveda is deeply rooted in personalized health management. While...

Descripción completa

Detalles Bibliográficos
Autores principales: Jnana, Apoorva, Murali, Thokur Sreepathy, Guruprasad, Kanive Parashiva, Satyamoorthy, Kapaettu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527847/
https://www.ncbi.nlm.nih.gov/pubmed/32718805
http://dx.doi.org/10.1016/j.jaim.2020.05.013
_version_ 1783589143385735168
author Jnana, Apoorva
Murali, Thokur Sreepathy
Guruprasad, Kanive Parashiva
Satyamoorthy, Kapaettu
author_facet Jnana, Apoorva
Murali, Thokur Sreepathy
Guruprasad, Kanive Parashiva
Satyamoorthy, Kapaettu
author_sort Jnana, Apoorva
collection PubMed
description Ayurveda has a rich history and its significance woven deeply in the Indian culture. The concept of prakriti (a person’s “nature” or constitutional type determined by the proportion of three doshas, namely - vata, pitta and kapha) in Ayurveda is deeply rooted in personalized health management. While the attributes of prakriti has been established to have a genomic basis, there is dearth of elaborate evidences linking prakriti with manifestation of diseases. Next generation sequencing studies have provided a causal link between variation in the gut microbiome and its effect on an individual’s fitness. Separately, reports have identified gut microbial patterns associated with several host variables such as geography, age, diet and extreme prakriti phenotypes. Recently, few reports have identified a “core gut microbiome” consisting of Bacteroides, Faecalibacterium, Prevotella and Ruminococcus prevalent across the Indian population; however, a few bacterial genera were specifically enriched in certain prakritis. Hence, in this review we aim to analyse the role of prakriti variations on dysbiosis of the gut microbiome and concomitantly its effect on human health. We suggest that prakriti phenotyping can function as a potential stratifier of the gut microbiome in a given population and may provide evidence for the conceptual framework of personalized medicine in Ayurvedic system of medicine.
format Online
Article
Text
id pubmed-7527847
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-75278472020-10-05 Prakriti phenotypes as a stratifier of gut microbiome: A new frontier in personalized medicine? Jnana, Apoorva Murali, Thokur Sreepathy Guruprasad, Kanive Parashiva Satyamoorthy, Kapaettu J Ayurveda Integr Med Short Review Ayurveda has a rich history and its significance woven deeply in the Indian culture. The concept of prakriti (a person’s “nature” or constitutional type determined by the proportion of three doshas, namely - vata, pitta and kapha) in Ayurveda is deeply rooted in personalized health management. While the attributes of prakriti has been established to have a genomic basis, there is dearth of elaborate evidences linking prakriti with manifestation of diseases. Next generation sequencing studies have provided a causal link between variation in the gut microbiome and its effect on an individual’s fitness. Separately, reports have identified gut microbial patterns associated with several host variables such as geography, age, diet and extreme prakriti phenotypes. Recently, few reports have identified a “core gut microbiome” consisting of Bacteroides, Faecalibacterium, Prevotella and Ruminococcus prevalent across the Indian population; however, a few bacterial genera were specifically enriched in certain prakritis. Hence, in this review we aim to analyse the role of prakriti variations on dysbiosis of the gut microbiome and concomitantly its effect on human health. We suggest that prakriti phenotyping can function as a potential stratifier of the gut microbiome in a given population and may provide evidence for the conceptual framework of personalized medicine in Ayurvedic system of medicine. Elsevier 2020 2020-07-25 /pmc/articles/PMC7527847/ /pubmed/32718805 http://dx.doi.org/10.1016/j.jaim.2020.05.013 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Review
Jnana, Apoorva
Murali, Thokur Sreepathy
Guruprasad, Kanive Parashiva
Satyamoorthy, Kapaettu
Prakriti phenotypes as a stratifier of gut microbiome: A new frontier in personalized medicine?
title Prakriti phenotypes as a stratifier of gut microbiome: A new frontier in personalized medicine?
title_full Prakriti phenotypes as a stratifier of gut microbiome: A new frontier in personalized medicine?
title_fullStr Prakriti phenotypes as a stratifier of gut microbiome: A new frontier in personalized medicine?
title_full_unstemmed Prakriti phenotypes as a stratifier of gut microbiome: A new frontier in personalized medicine?
title_short Prakriti phenotypes as a stratifier of gut microbiome: A new frontier in personalized medicine?
title_sort prakriti phenotypes as a stratifier of gut microbiome: a new frontier in personalized medicine?
topic Short Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527847/
https://www.ncbi.nlm.nih.gov/pubmed/32718805
http://dx.doi.org/10.1016/j.jaim.2020.05.013
work_keys_str_mv AT jnanaapoorva prakritiphenotypesasastratifierofgutmicrobiomeanewfrontierinpersonalizedmedicine
AT muralithokursreepathy prakritiphenotypesasastratifierofgutmicrobiomeanewfrontierinpersonalizedmedicine
AT guruprasadkaniveparashiva prakritiphenotypesasastratifierofgutmicrobiomeanewfrontierinpersonalizedmedicine
AT satyamoorthykapaettu prakritiphenotypesasastratifierofgutmicrobiomeanewfrontierinpersonalizedmedicine