COPA silences STING

Two studies published in this issue of JEM, by Lepelley et al. (https://doi.org/10.1084/jem.20200600) and Deng et al. (https://doi.org/10.1084/jem.20201045), and two additional manuscripts by Mukai et al. (https://doi.org/10.1101/2020.05.20.107664 Preprint v1) and Steiner et al. (https://doi.org/10....

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Detalles Bibliográficos
Autores principales: Rivara, Sophie, Ablasser, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527967/
https://www.ncbi.nlm.nih.gov/pubmed/32991673
http://dx.doi.org/10.1084/jem.20201517
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author Rivara, Sophie
Ablasser, Andrea
author_facet Rivara, Sophie
Ablasser, Andrea
author_sort Rivara, Sophie
collection PubMed
description Two studies published in this issue of JEM, by Lepelley et al. (https://doi.org/10.1084/jem.20200600) and Deng et al. (https://doi.org/10.1084/jem.20201045), and two additional manuscripts by Mukai et al. (https://doi.org/10.1101/2020.05.20.107664 Preprint v1) and Steiner et al. (https://doi.org/10.1101/2020.07.09.194399 Preprint v1) demonstrate that COPA syndrome–associated high interferon titers are linked to mutations in COPA preventing STING’s retrieval from the Golgi back to the ER and thereby causing chronic immune activation.
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spelling pubmed-75279672021-05-02 COPA silences STING Rivara, Sophie Ablasser, Andrea J Exp Med Insights Two studies published in this issue of JEM, by Lepelley et al. (https://doi.org/10.1084/jem.20200600) and Deng et al. (https://doi.org/10.1084/jem.20201045), and two additional manuscripts by Mukai et al. (https://doi.org/10.1101/2020.05.20.107664 Preprint v1) and Steiner et al. (https://doi.org/10.1101/2020.07.09.194399 Preprint v1) demonstrate that COPA syndrome–associated high interferon titers are linked to mutations in COPA preventing STING’s retrieval from the Golgi back to the ER and thereby causing chronic immune activation. Rockefeller University Press 2020-09-29 /pmc/articles/PMC7527967/ /pubmed/32991673 http://dx.doi.org/10.1084/jem.20201517 Text en © 2020 Rivara and Ablasser http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Rivara, Sophie
Ablasser, Andrea
COPA silences STING
title COPA silences STING
title_full COPA silences STING
title_fullStr COPA silences STING
title_full_unstemmed COPA silences STING
title_short COPA silences STING
title_sort copa silences sting
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527967/
https://www.ncbi.nlm.nih.gov/pubmed/32991673
http://dx.doi.org/10.1084/jem.20201517
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