Cargando…

Changes in the Demographic and Clinicopathological Characteristics of Thyroid Cancer: A Population-Based Investigation in Algeria, 1993-2013

Over the last three decades, the incidence of thyroid cancer has increased worldwide. The reasons for this increase remain controversial. In Algeria, however, to date, information on thyroid cancer has been limited to a hospital-based case series. We analyzed data from a population-based cohort stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Boukheris, Houda, Bettayeb, Arslan, Anderson, Lesley Ann, Achour, Zineb, Benbachir, Fatma Zohra, Attar, Sarra, Saim, Hafida, Rouigeb, Kada, Berber, Necib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528096/
https://www.ncbi.nlm.nih.gov/pubmed/33029144
http://dx.doi.org/10.1155/2020/7812791
_version_ 1783589190364037120
author Boukheris, Houda
Bettayeb, Arslan
Anderson, Lesley Ann
Achour, Zineb
Benbachir, Fatma Zohra
Attar, Sarra
Saim, Hafida
Rouigeb, Kada
Berber, Necib
author_facet Boukheris, Houda
Bettayeb, Arslan
Anderson, Lesley Ann
Achour, Zineb
Benbachir, Fatma Zohra
Attar, Sarra
Saim, Hafida
Rouigeb, Kada
Berber, Necib
author_sort Boukheris, Houda
collection PubMed
description Over the last three decades, the incidence of thyroid cancer has increased worldwide. The reasons for this increase remain controversial. In Algeria, however, to date, information on thyroid cancer has been limited to a hospital-based case series. We analyzed data from a population-based cohort study in Oran District, Algeria, to describe demographic and clinicopathological characteristics of patients diagnosed with thyroid cancer between 1993 and 2013. Medical records and pathology reports of thyroid cancer patients who had surgery were reviewed. Changes in demographic and clinicopathological features over the 21-year period are described. During the study period, thyroid cancer was diagnosed in 1248 women (86.5%, mean age 43.7 ± 15.2 years) and 195 men (23.4%, mean age 48.1 ± 15.9 years). Most cases (83.1% for women and 69.8% for men) sought a diagnosis following a self-neck check. The most common histologic types were papillary (58.3%), follicular (29.7%), anaplastic (4.1%), and medullary (0.8%) carcinomas. The incidence of papillary carcinomas significantly increased (p < 0.001) while the incidence of other histologic types significantly decreased over time. Tumor size overall significantly decreased (p < 0.001) while the frequency of small (≤20 mm) and larger (>20 mm) carcinomas significantly increased (p < 0.05). The frequency of thyroid cancers with capsular effractions and angioinvasions also decreased over time. Thyroid cancer incidence in Algeria has increased substantially in line with international trends with changes in clinical practice being a possible contributing factor. However, the increasing papillary-to-follicular cancer ratio may be due to changes in iodine nutrition status in Algeria. Further research, including exploration of biological and molecular features of thyroid cancer, will enable a better understanding of risk factors and etiopathogenetic mechanisms.
format Online
Article
Text
id pubmed-7528096
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-75280962020-10-06 Changes in the Demographic and Clinicopathological Characteristics of Thyroid Cancer: A Population-Based Investigation in Algeria, 1993-2013 Boukheris, Houda Bettayeb, Arslan Anderson, Lesley Ann Achour, Zineb Benbachir, Fatma Zohra Attar, Sarra Saim, Hafida Rouigeb, Kada Berber, Necib J Cancer Epidemiol Research Article Over the last three decades, the incidence of thyroid cancer has increased worldwide. The reasons for this increase remain controversial. In Algeria, however, to date, information on thyroid cancer has been limited to a hospital-based case series. We analyzed data from a population-based cohort study in Oran District, Algeria, to describe demographic and clinicopathological characteristics of patients diagnosed with thyroid cancer between 1993 and 2013. Medical records and pathology reports of thyroid cancer patients who had surgery were reviewed. Changes in demographic and clinicopathological features over the 21-year period are described. During the study period, thyroid cancer was diagnosed in 1248 women (86.5%, mean age 43.7 ± 15.2 years) and 195 men (23.4%, mean age 48.1 ± 15.9 years). Most cases (83.1% for women and 69.8% for men) sought a diagnosis following a self-neck check. The most common histologic types were papillary (58.3%), follicular (29.7%), anaplastic (4.1%), and medullary (0.8%) carcinomas. The incidence of papillary carcinomas significantly increased (p < 0.001) while the incidence of other histologic types significantly decreased over time. Tumor size overall significantly decreased (p < 0.001) while the frequency of small (≤20 mm) and larger (>20 mm) carcinomas significantly increased (p < 0.05). The frequency of thyroid cancers with capsular effractions and angioinvasions also decreased over time. Thyroid cancer incidence in Algeria has increased substantially in line with international trends with changes in clinical practice being a possible contributing factor. However, the increasing papillary-to-follicular cancer ratio may be due to changes in iodine nutrition status in Algeria. Further research, including exploration of biological and molecular features of thyroid cancer, will enable a better understanding of risk factors and etiopathogenetic mechanisms. Hindawi 2020-09-22 /pmc/articles/PMC7528096/ /pubmed/33029144 http://dx.doi.org/10.1155/2020/7812791 Text en Copyright © 2020 Houda Boukheris et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Boukheris, Houda
Bettayeb, Arslan
Anderson, Lesley Ann
Achour, Zineb
Benbachir, Fatma Zohra
Attar, Sarra
Saim, Hafida
Rouigeb, Kada
Berber, Necib
Changes in the Demographic and Clinicopathological Characteristics of Thyroid Cancer: A Population-Based Investigation in Algeria, 1993-2013
title Changes in the Demographic and Clinicopathological Characteristics of Thyroid Cancer: A Population-Based Investigation in Algeria, 1993-2013
title_full Changes in the Demographic and Clinicopathological Characteristics of Thyroid Cancer: A Population-Based Investigation in Algeria, 1993-2013
title_fullStr Changes in the Demographic and Clinicopathological Characteristics of Thyroid Cancer: A Population-Based Investigation in Algeria, 1993-2013
title_full_unstemmed Changes in the Demographic and Clinicopathological Characteristics of Thyroid Cancer: A Population-Based Investigation in Algeria, 1993-2013
title_short Changes in the Demographic and Clinicopathological Characteristics of Thyroid Cancer: A Population-Based Investigation in Algeria, 1993-2013
title_sort changes in the demographic and clinicopathological characteristics of thyroid cancer: a population-based investigation in algeria, 1993-2013
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528096/
https://www.ncbi.nlm.nih.gov/pubmed/33029144
http://dx.doi.org/10.1155/2020/7812791
work_keys_str_mv AT boukherishouda changesinthedemographicandclinicopathologicalcharacteristicsofthyroidcancerapopulationbasedinvestigationinalgeria19932013
AT bettayebarslan changesinthedemographicandclinicopathologicalcharacteristicsofthyroidcancerapopulationbasedinvestigationinalgeria19932013
AT andersonlesleyann changesinthedemographicandclinicopathologicalcharacteristicsofthyroidcancerapopulationbasedinvestigationinalgeria19932013
AT achourzineb changesinthedemographicandclinicopathologicalcharacteristicsofthyroidcancerapopulationbasedinvestigationinalgeria19932013
AT benbachirfatmazohra changesinthedemographicandclinicopathologicalcharacteristicsofthyroidcancerapopulationbasedinvestigationinalgeria19932013
AT attarsarra changesinthedemographicandclinicopathologicalcharacteristicsofthyroidcancerapopulationbasedinvestigationinalgeria19932013
AT saimhafida changesinthedemographicandclinicopathologicalcharacteristicsofthyroidcancerapopulationbasedinvestigationinalgeria19932013
AT rouigebkada changesinthedemographicandclinicopathologicalcharacteristicsofthyroidcancerapopulationbasedinvestigationinalgeria19932013
AT berbernecib changesinthedemographicandclinicopathologicalcharacteristicsofthyroidcancerapopulationbasedinvestigationinalgeria19932013