Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer

An 85-year-old woman with antibiotics-resistant pneumonia after surgery for metastatic brain tumor from lung cancer was consulted to our department. Chest CT showed diffuse GGO bilaterally. BALF showed elevated ratios of lymphocytes and CD4/CD8. Tests for bacteria, mycobacteria, and fungi were negat...

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Detalles Bibliográficos
Autores principales: Sato, Shintaro, Oba, Tomohiro, Ohta, Hiroki, Tsukahara, Yuta, Kida, Gen, Tsumiyama, Emiri, Kusano, Kenji, Nishizawa, Tomotaka, Kawabe, Rie, Yamakawa, Hideaki, Akasaka, Keiichi, Amano, Masako, Matsushima, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528199/
https://www.ncbi.nlm.nih.gov/pubmed/33024691
http://dx.doi.org/10.1016/j.rmcr.2020.101241
Descripción
Sumario:An 85-year-old woman with antibiotics-resistant pneumonia after surgery for metastatic brain tumor from lung cancer was consulted to our department. Chest CT showed diffuse GGO bilaterally. BALF showed elevated ratios of lymphocytes and CD4/CD8. Tests for bacteria, mycobacteria, and fungi were negative. She improved following levetiracetam discontinuance and systemic corticosteroid administration, and we diagnosed levetiracetam-induced lung injury. Although levetiracetam is widely used, few reports of levetiracetam-induced pneumonia exist. Changes in chest images may occur after levetiracetam administration if patients have multiple risk factors for development of drug-induced interstitial lung disease. Bronchoscopy is useful for differential diagnosis if new lung lesions appear after starting levetiracetam.

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