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Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer

An 85-year-old woman with antibiotics-resistant pneumonia after surgery for metastatic brain tumor from lung cancer was consulted to our department. Chest CT showed diffuse GGO bilaterally. BALF showed elevated ratios of lymphocytes and CD4/CD8. Tests for bacteria, mycobacteria, and fungi were negat...

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Autores principales: Sato, Shintaro, Oba, Tomohiro, Ohta, Hiroki, Tsukahara, Yuta, Kida, Gen, Tsumiyama, Emiri, Kusano, Kenji, Nishizawa, Tomotaka, Kawabe, Rie, Yamakawa, Hideaki, Akasaka, Keiichi, Amano, Masako, Matsushima, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528199/
https://www.ncbi.nlm.nih.gov/pubmed/33024691
http://dx.doi.org/10.1016/j.rmcr.2020.101241
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author Sato, Shintaro
Oba, Tomohiro
Ohta, Hiroki
Tsukahara, Yuta
Kida, Gen
Tsumiyama, Emiri
Kusano, Kenji
Nishizawa, Tomotaka
Kawabe, Rie
Yamakawa, Hideaki
Akasaka, Keiichi
Amano, Masako
Matsushima, Hidekazu
author_facet Sato, Shintaro
Oba, Tomohiro
Ohta, Hiroki
Tsukahara, Yuta
Kida, Gen
Tsumiyama, Emiri
Kusano, Kenji
Nishizawa, Tomotaka
Kawabe, Rie
Yamakawa, Hideaki
Akasaka, Keiichi
Amano, Masako
Matsushima, Hidekazu
author_sort Sato, Shintaro
collection PubMed
description An 85-year-old woman with antibiotics-resistant pneumonia after surgery for metastatic brain tumor from lung cancer was consulted to our department. Chest CT showed diffuse GGO bilaterally. BALF showed elevated ratios of lymphocytes and CD4/CD8. Tests for bacteria, mycobacteria, and fungi were negative. She improved following levetiracetam discontinuance and systemic corticosteroid administration, and we diagnosed levetiracetam-induced lung injury. Although levetiracetam is widely used, few reports of levetiracetam-induced pneumonia exist. Changes in chest images may occur after levetiracetam administration if patients have multiple risk factors for development of drug-induced interstitial lung disease. Bronchoscopy is useful for differential diagnosis if new lung lesions appear after starting levetiracetam.
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spelling pubmed-75281992020-10-05 Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer Sato, Shintaro Oba, Tomohiro Ohta, Hiroki Tsukahara, Yuta Kida, Gen Tsumiyama, Emiri Kusano, Kenji Nishizawa, Tomotaka Kawabe, Rie Yamakawa, Hideaki Akasaka, Keiichi Amano, Masako Matsushima, Hidekazu Respir Med Case Rep Case Report An 85-year-old woman with antibiotics-resistant pneumonia after surgery for metastatic brain tumor from lung cancer was consulted to our department. Chest CT showed diffuse GGO bilaterally. BALF showed elevated ratios of lymphocytes and CD4/CD8. Tests for bacteria, mycobacteria, and fungi were negative. She improved following levetiracetam discontinuance and systemic corticosteroid administration, and we diagnosed levetiracetam-induced lung injury. Although levetiracetam is widely used, few reports of levetiracetam-induced pneumonia exist. Changes in chest images may occur after levetiracetam administration if patients have multiple risk factors for development of drug-induced interstitial lung disease. Bronchoscopy is useful for differential diagnosis if new lung lesions appear after starting levetiracetam. Elsevier 2020-09-28 /pmc/articles/PMC7528199/ /pubmed/33024691 http://dx.doi.org/10.1016/j.rmcr.2020.101241 Text en © 2020 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sato, Shintaro
Oba, Tomohiro
Ohta, Hiroki
Tsukahara, Yuta
Kida, Gen
Tsumiyama, Emiri
Kusano, Kenji
Nishizawa, Tomotaka
Kawabe, Rie
Yamakawa, Hideaki
Akasaka, Keiichi
Amano, Masako
Matsushima, Hidekazu
Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer
title Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer
title_full Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer
title_fullStr Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer
title_full_unstemmed Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer
title_short Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer
title_sort levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528199/
https://www.ncbi.nlm.nih.gov/pubmed/33024691
http://dx.doi.org/10.1016/j.rmcr.2020.101241
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