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Blood gene transcript signature profiling in pregnancies resulting in preterm birth: A systematic review

OBJECTIVE: To pursue a systematic review and summarise the current evidence for the potential of transcriptome molecular profiling in investigating the preterm phenotype. STUDY DESIGN: We systematically reviewed the literature, using readily available electronic databases (i.e. PubMed/Medline, Embas...

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Autores principales: Brummaier, Tobias, Kabeer, Basirudeen Syed Ahamed, Chaussabel, Damien, Utzinger, Jürg, McGready, Rose, Paris, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528201/
https://www.ncbi.nlm.nih.gov/pubmed/33024956
http://dx.doi.org/10.1016/j.eurox.2020.100118
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author Brummaier, Tobias
Kabeer, Basirudeen Syed Ahamed
Chaussabel, Damien
Utzinger, Jürg
McGready, Rose
Paris, Daniel H.
author_facet Brummaier, Tobias
Kabeer, Basirudeen Syed Ahamed
Chaussabel, Damien
Utzinger, Jürg
McGready, Rose
Paris, Daniel H.
author_sort Brummaier, Tobias
collection PubMed
description OBJECTIVE: To pursue a systematic review and summarise the current evidence for the potential of transcriptome molecular profiling in investigating the preterm phenotype. STUDY DESIGN: We systematically reviewed the literature, using readily available electronic databases (i.e. PubMed/Medline, Embase, Scopus and Web of Science) from inception until March 2020 to identify investigations of maternal blood-derived RNA profiling in preterm birth (PTB). Studies were included if circulating coding or non-coding RNA was analysed in maternal blood during pregnancy and/or at delivery. Interventional trials were not included. The primary outcome was the availability of whole genome expression patterns evaluated in pregnancies resulting in preterm deliveries. RESULTS: A total of 35 articles were included in the final analysis. Most of the studies were conducted in high-income countries and published in the last decade. Apart from spontaneous PTB, a variety of phenotypes leading to preterm delivery were reported. Differences in sampling methods, target gene selection and laboratory protocols severely limited any quantitative comparisons. Most of the studies revealed that gene expression profiling during pregnancy has high potential for identifying women at risk of spontaneous and/or non-spontaneous PTB as early as in the first trimester. CONCLUSION: Assessing maternal blood-derived transcriptional signatures for PTB risk in pregnant women holds promise as a screening approach. However, longitudinally followed, prospective pregnancy cohorts are lacking. These are relevant for identifying causes leading to PTB and whether prediction of spontaneous PTB or co-morbidities associated with PTB is achievable. More emphasis on widely employed standardised protocols is required to ensure comparability of results.
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spelling pubmed-75282012020-10-05 Blood gene transcript signature profiling in pregnancies resulting in preterm birth: A systematic review Brummaier, Tobias Kabeer, Basirudeen Syed Ahamed Chaussabel, Damien Utzinger, Jürg McGready, Rose Paris, Daniel H. Eur J Obstet Gynecol Reprod Biol X Review OBJECTIVE: To pursue a systematic review and summarise the current evidence for the potential of transcriptome molecular profiling in investigating the preterm phenotype. STUDY DESIGN: We systematically reviewed the literature, using readily available electronic databases (i.e. PubMed/Medline, Embase, Scopus and Web of Science) from inception until March 2020 to identify investigations of maternal blood-derived RNA profiling in preterm birth (PTB). Studies were included if circulating coding or non-coding RNA was analysed in maternal blood during pregnancy and/or at delivery. Interventional trials were not included. The primary outcome was the availability of whole genome expression patterns evaluated in pregnancies resulting in preterm deliveries. RESULTS: A total of 35 articles were included in the final analysis. Most of the studies were conducted in high-income countries and published in the last decade. Apart from spontaneous PTB, a variety of phenotypes leading to preterm delivery were reported. Differences in sampling methods, target gene selection and laboratory protocols severely limited any quantitative comparisons. Most of the studies revealed that gene expression profiling during pregnancy has high potential for identifying women at risk of spontaneous and/or non-spontaneous PTB as early as in the first trimester. CONCLUSION: Assessing maternal blood-derived transcriptional signatures for PTB risk in pregnant women holds promise as a screening approach. However, longitudinally followed, prospective pregnancy cohorts are lacking. These are relevant for identifying causes leading to PTB and whether prediction of spontaneous PTB or co-morbidities associated with PTB is achievable. More emphasis on widely employed standardised protocols is required to ensure comparability of results. Elsevier 2020-09-22 /pmc/articles/PMC7528201/ /pubmed/33024956 http://dx.doi.org/10.1016/j.eurox.2020.100118 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Brummaier, Tobias
Kabeer, Basirudeen Syed Ahamed
Chaussabel, Damien
Utzinger, Jürg
McGready, Rose
Paris, Daniel H.
Blood gene transcript signature profiling in pregnancies resulting in preterm birth: A systematic review
title Blood gene transcript signature profiling in pregnancies resulting in preterm birth: A systematic review
title_full Blood gene transcript signature profiling in pregnancies resulting in preterm birth: A systematic review
title_fullStr Blood gene transcript signature profiling in pregnancies resulting in preterm birth: A systematic review
title_full_unstemmed Blood gene transcript signature profiling in pregnancies resulting in preterm birth: A systematic review
title_short Blood gene transcript signature profiling in pregnancies resulting in preterm birth: A systematic review
title_sort blood gene transcript signature profiling in pregnancies resulting in preterm birth: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528201/
https://www.ncbi.nlm.nih.gov/pubmed/33024956
http://dx.doi.org/10.1016/j.eurox.2020.100118
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