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Arthroscopic Chondral Defect Repair With Extracellular Matrix Scaffold and Bone Marrow Aspirate Concentrate

Chondral defects of the knee are prevalent and often encountered during arthroscopic procedures. Despite the limited healing potential of chondral defects, several treatment options have been proposed. However, microfracture, osteochondral autograft (or allograft) transfer, autologous chondrocyte im...

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Autores principales: Dávila Castrodad, Iciar M., Mease, Samuel J., Werheim, Erik, McInerney, Vincent K., Scillia, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528213/
https://www.ncbi.nlm.nih.gov/pubmed/33024662
http://dx.doi.org/10.1016/j.eats.2020.05.001
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author Dávila Castrodad, Iciar M.
Mease, Samuel J.
Werheim, Erik
McInerney, Vincent K.
Scillia, Anthony J.
author_facet Dávila Castrodad, Iciar M.
Mease, Samuel J.
Werheim, Erik
McInerney, Vincent K.
Scillia, Anthony J.
author_sort Dávila Castrodad, Iciar M.
collection PubMed
description Chondral defects of the knee are prevalent and often encountered during arthroscopic procedures. Despite the limited healing potential of chondral defects, several treatment options have been proposed. However, microfracture, osteochondral autograft (or allograft) transfer, autologous chondrocyte implantation, and matrix-induced autologous chondrocyte implantation are all associated with their respective shortcomings. As such, the optimal treatment for chondral defects of the knee remains unclear. Recently, many authors have advocated treating chondral defects with biological therapies and scaffold-based treatments. Bone marrow aspirate concentrate, a cell-based injection, has gained particular attention because of its differentiation capacity and potential role in tissue regeneration. In addition, scaffold cartilage treatments have emerged and reached clinical practice. BioCartilage is one form of scaffold, which consists of extracellular matrix, and has been claimed to promote the regeneration of hyaline-like cartilage. This article presents our technique of arthroscopic chondral defect repair using BMAC and BioCartilage.
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spelling pubmed-75282132020-10-05 Arthroscopic Chondral Defect Repair With Extracellular Matrix Scaffold and Bone Marrow Aspirate Concentrate Dávila Castrodad, Iciar M. Mease, Samuel J. Werheim, Erik McInerney, Vincent K. Scillia, Anthony J. Arthrosc Tech Technical Note Chondral defects of the knee are prevalent and often encountered during arthroscopic procedures. Despite the limited healing potential of chondral defects, several treatment options have been proposed. However, microfracture, osteochondral autograft (or allograft) transfer, autologous chondrocyte implantation, and matrix-induced autologous chondrocyte implantation are all associated with their respective shortcomings. As such, the optimal treatment for chondral defects of the knee remains unclear. Recently, many authors have advocated treating chondral defects with biological therapies and scaffold-based treatments. Bone marrow aspirate concentrate, a cell-based injection, has gained particular attention because of its differentiation capacity and potential role in tissue regeneration. In addition, scaffold cartilage treatments have emerged and reached clinical practice. BioCartilage is one form of scaffold, which consists of extracellular matrix, and has been claimed to promote the regeneration of hyaline-like cartilage. This article presents our technique of arthroscopic chondral defect repair using BMAC and BioCartilage. Elsevier 2020-09-06 /pmc/articles/PMC7528213/ /pubmed/33024662 http://dx.doi.org/10.1016/j.eats.2020.05.001 Text en © 2020 by the Arthroscopy Association of North America. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Technical Note
Dávila Castrodad, Iciar M.
Mease, Samuel J.
Werheim, Erik
McInerney, Vincent K.
Scillia, Anthony J.
Arthroscopic Chondral Defect Repair With Extracellular Matrix Scaffold and Bone Marrow Aspirate Concentrate
title Arthroscopic Chondral Defect Repair With Extracellular Matrix Scaffold and Bone Marrow Aspirate Concentrate
title_full Arthroscopic Chondral Defect Repair With Extracellular Matrix Scaffold and Bone Marrow Aspirate Concentrate
title_fullStr Arthroscopic Chondral Defect Repair With Extracellular Matrix Scaffold and Bone Marrow Aspirate Concentrate
title_full_unstemmed Arthroscopic Chondral Defect Repair With Extracellular Matrix Scaffold and Bone Marrow Aspirate Concentrate
title_short Arthroscopic Chondral Defect Repair With Extracellular Matrix Scaffold and Bone Marrow Aspirate Concentrate
title_sort arthroscopic chondral defect repair with extracellular matrix scaffold and bone marrow aspirate concentrate
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528213/
https://www.ncbi.nlm.nih.gov/pubmed/33024662
http://dx.doi.org/10.1016/j.eats.2020.05.001
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