Dnmt3b regulates DUX4 expression in a tissue-dependent manner in transgenic D4Z4 mice

BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD) is a skeletal muscle disorder that is caused by derepression of the transcription factor DUX4 in skeletal muscle cells. Apart from SMCHD1, DNMT3B was recently identified as a disease gene and disease modifier in FSHD. However, the exact role...

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Detalles Bibliográficos
Autores principales: Bouwman, Linde F., den Hamer, Bianca, Verveer, Elwin P., Lerink, Lente J. S., Krom, Yvonne D., van der Maarel, Silvère M., de Greef, Jessica C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528343/
https://www.ncbi.nlm.nih.gov/pubmed/33004076
http://dx.doi.org/10.1186/s13395-020-00247-0

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