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New Aspects of the Epigenetics of Pancreatic Carcinogenesis

Pancreatic cancer remains among the deadliest forms of cancer with a 5 year survival rate less than 10%. With increasing numbers being observed, there is an urgent need to elucidate the pathogenesis of pancreatic cancer. While both contribute to disease progression, neither genetic nor environmental...

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Autores principales: Toruner, Murat, Fernandez-Zapico, Martin E., Pin, Christopher L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528595/
https://www.ncbi.nlm.nih.gov/pubmed/33014438
http://dx.doi.org/10.3390/epigenomes4030018
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author Toruner, Murat
Fernandez-Zapico, Martin E.
Pin, Christopher L.
author_facet Toruner, Murat
Fernandez-Zapico, Martin E.
Pin, Christopher L.
author_sort Toruner, Murat
collection PubMed
description Pancreatic cancer remains among the deadliest forms of cancer with a 5 year survival rate less than 10%. With increasing numbers being observed, there is an urgent need to elucidate the pathogenesis of pancreatic cancer. While both contribute to disease progression, neither genetic nor environmental factors completely explain susceptibility or pathogenesis. Defining the links between genetic and environmental events represents an opportunity to understand the pathogenesis of pancreatic cancer. Epigenetics, the study of mitotically heritable changes in genome function without a change in nucleotide sequence, is an emerging field of research in pancreatic cancer. The main epigenetic mechanisms include DNA methylation, histone modifications and RNA interference, all of which are altered by changes to the environment. Epigenetic mechanisms are being investigated to clarify the underlying pathogenesis of pancreatic cancer including an increasing number of studies examining the role as possible diagnostic and prognostic biomarkers. These mechanisms also provide targets for promising new therapeutic approaches for this devastating malignancy.
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spelling pubmed-75285952020-10-01 New Aspects of the Epigenetics of Pancreatic Carcinogenesis Toruner, Murat Fernandez-Zapico, Martin E. Pin, Christopher L. Epigenomes Editorial Pancreatic cancer remains among the deadliest forms of cancer with a 5 year survival rate less than 10%. With increasing numbers being observed, there is an urgent need to elucidate the pathogenesis of pancreatic cancer. While both contribute to disease progression, neither genetic nor environmental factors completely explain susceptibility or pathogenesis. Defining the links between genetic and environmental events represents an opportunity to understand the pathogenesis of pancreatic cancer. Epigenetics, the study of mitotically heritable changes in genome function without a change in nucleotide sequence, is an emerging field of research in pancreatic cancer. The main epigenetic mechanisms include DNA methylation, histone modifications and RNA interference, all of which are altered by changes to the environment. Epigenetic mechanisms are being investigated to clarify the underlying pathogenesis of pancreatic cancer including an increasing number of studies examining the role as possible diagnostic and prognostic biomarkers. These mechanisms also provide targets for promising new therapeutic approaches for this devastating malignancy. MDPI 2020-08-31 /pmc/articles/PMC7528595/ /pubmed/33014438 http://dx.doi.org/10.3390/epigenomes4030018 Text en © 2020 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Editorial
Toruner, Murat
Fernandez-Zapico, Martin E.
Pin, Christopher L.
New Aspects of the Epigenetics of Pancreatic Carcinogenesis
title New Aspects of the Epigenetics of Pancreatic Carcinogenesis
title_full New Aspects of the Epigenetics of Pancreatic Carcinogenesis
title_fullStr New Aspects of the Epigenetics of Pancreatic Carcinogenesis
title_full_unstemmed New Aspects of the Epigenetics of Pancreatic Carcinogenesis
title_short New Aspects of the Epigenetics of Pancreatic Carcinogenesis
title_sort new aspects of the epigenetics of pancreatic carcinogenesis
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528595/
https://www.ncbi.nlm.nih.gov/pubmed/33014438
http://dx.doi.org/10.3390/epigenomes4030018
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