Point-activated ESR1(Y541S) has a dramatic effect on the development of sexually dimorphic organs

Mutations in the estrogen receptor α (ERα) occur in endocrine-resistant metastatic breast cancer. However, a major gap persists with the lack of genetically tractable immune competent mouse models to study disease. Hence, we developed a Cre-inducible murine model expressing a point-activated ESR1(Y5...

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Detalles Bibliográficos
Autores principales: Simond, Alexandra M., Ling, Chen, Moore, Michaela J., Condotta, Stephanie A., Richer, Martin J., Muller, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528702/
https://www.ncbi.nlm.nih.gov/pubmed/32912899
http://dx.doi.org/10.1101/gad.339424.120

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