AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation

Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the AMPK and the mTORC1 pathway in the hepatic benefits of metformin are still ill defined. Metformin...

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Detalles Bibliográficos
Autores principales: Van Nostrand, Jeanine L., Hellberg, Kristina, Luo, En-Ching, Van Nostrand, Eric L., Dayn, Alina, Yu, Jingting, Shokhirev, Maxim N., Dayn, Yelena, Yeo, Gene W., Shaw, Reuben J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528705/
https://www.ncbi.nlm.nih.gov/pubmed/32912901
http://dx.doi.org/10.1101/gad.339895.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528705/
https://www.ncbi.nlm.nih.gov/pubmed/32912901
http://dx.doi.org/10.1101/gad.339895.120

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