L−Lysine Amino Acid Adsorption on Zeolite L: a Combined Synchrotron, X‐Ray and Neutron Diffraction Study

Combined neutron and X‐ray powder diffraction techniques highlighted the sorption capacity of the acidic L zeolite towards the L‐lysine amino acid. The role of zeolite channels in the stabilization of the lysine absorbed and the effect of water on protein structure are elucidated at atomistic level....

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Autores principales: Beltrami, Giada, Martucci, Annalisa, Pasti, Luisa, Chenet, Tatiana, Ardit, Matteo, Gigli, Lara, Cescon, Mirco, Suard, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528762/
https://www.ncbi.nlm.nih.gov/pubmed/33024651
http://dx.doi.org/10.1002/open.202000183
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author Beltrami, Giada
Martucci, Annalisa
Pasti, Luisa
Chenet, Tatiana
Ardit, Matteo
Gigli, Lara
Cescon, Mirco
Suard, Emmanuelle
author_facet Beltrami, Giada
Martucci, Annalisa
Pasti, Luisa
Chenet, Tatiana
Ardit, Matteo
Gigli, Lara
Cescon, Mirco
Suard, Emmanuelle
author_sort Beltrami, Giada
collection PubMed
description Combined neutron and X‐ray powder diffraction techniques highlighted the sorption capacity of the acidic L zeolite towards the L‐lysine amino acid. The role of zeolite channels in the stabilization of the lysine absorbed and the effect of water on protein structure are elucidated at atomistic level. The stabilization of the L α‐helical conformation is related to strong H‐bonds between the tail aminogroups of lysine molecules and the Brønsted acid site as well as to complex intermolecular H‐bond system between water molecules, zeolite and amino acid. This finding is relevant in the catalytic synthesis of polypeptide, as well as in industrial biotechnology by qualitatively predicting binding behaviour
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spelling pubmed-75287622020-10-05 L−Lysine Amino Acid Adsorption on Zeolite L: a Combined Synchrotron, X‐Ray and Neutron Diffraction Study Beltrami, Giada Martucci, Annalisa Pasti, Luisa Chenet, Tatiana Ardit, Matteo Gigli, Lara Cescon, Mirco Suard, Emmanuelle ChemistryOpen Full Papers Combined neutron and X‐ray powder diffraction techniques highlighted the sorption capacity of the acidic L zeolite towards the L‐lysine amino acid. The role of zeolite channels in the stabilization of the lysine absorbed and the effect of water on protein structure are elucidated at atomistic level. The stabilization of the L α‐helical conformation is related to strong H‐bonds between the tail aminogroups of lysine molecules and the Brønsted acid site as well as to complex intermolecular H‐bond system between water molecules, zeolite and amino acid. This finding is relevant in the catalytic synthesis of polypeptide, as well as in industrial biotechnology by qualitatively predicting binding behaviour John Wiley and Sons Inc. 2020-09-24 /pmc/articles/PMC7528762/ /pubmed/33024651 http://dx.doi.org/10.1002/open.202000183 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Full Papers
Beltrami, Giada
Martucci, Annalisa
Pasti, Luisa
Chenet, Tatiana
Ardit, Matteo
Gigli, Lara
Cescon, Mirco
Suard, Emmanuelle
L−Lysine Amino Acid Adsorption on Zeolite L: a Combined Synchrotron, X‐Ray and Neutron Diffraction Study
title L−Lysine Amino Acid Adsorption on Zeolite L: a Combined Synchrotron, X‐Ray and Neutron Diffraction Study
title_full L−Lysine Amino Acid Adsorption on Zeolite L: a Combined Synchrotron, X‐Ray and Neutron Diffraction Study
title_fullStr L−Lysine Amino Acid Adsorption on Zeolite L: a Combined Synchrotron, X‐Ray and Neutron Diffraction Study
title_full_unstemmed L−Lysine Amino Acid Adsorption on Zeolite L: a Combined Synchrotron, X‐Ray and Neutron Diffraction Study
title_short L−Lysine Amino Acid Adsorption on Zeolite L: a Combined Synchrotron, X‐Ray and Neutron Diffraction Study
title_sort l−lysine amino acid adsorption on zeolite l: a combined synchrotron, x‐ray and neutron diffraction study
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528762/
https://www.ncbi.nlm.nih.gov/pubmed/33024651
http://dx.doi.org/10.1002/open.202000183
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