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More Severe Hypercoagulable State in Acute COVID-19 Pneumonia as Compared With Other Pneumonia
OBJECTIVE: To conduct a comprehensive evaluation of coagulation profiles—via traditional and whole blood thromboelastometry tests—in coronavirus disease 2019 (COVID-19)–positive vs COVID-19–negative patients admitted to medical wards for acute pneumonia. PATIENTS AND METHODS: We enrolled all consecu...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528900/ https://www.ncbi.nlm.nih.gov/pubmed/33024937 http://dx.doi.org/10.1016/j.mayocpiqo.2020.09.002 |
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author | Spiezia, Luca Campello, Elena Cola, Marco Poletto, Francesco Cerruti, Lorenzo Poretto, Anna Simion, Chiara Cattelan, Annamaria Vettor, Roberto Simioni, Paolo |
author_facet | Spiezia, Luca Campello, Elena Cola, Marco Poletto, Francesco Cerruti, Lorenzo Poretto, Anna Simion, Chiara Cattelan, Annamaria Vettor, Roberto Simioni, Paolo |
author_sort | Spiezia, Luca |
collection | PubMed |
description | OBJECTIVE: To conduct a comprehensive evaluation of coagulation profiles—via traditional and whole blood thromboelastometry tests—in coronavirus disease 2019 (COVID-19)–positive vs COVID-19–negative patients admitted to medical wards for acute pneumonia. PATIENTS AND METHODS: We enrolled all consecutive patients admitted to internal medicine wards of Padova University Hospital between 7 March and 30 April, 2020, for COVID-19–related pneumonia (cases) vs non–COVID-19 pneumonia (controls). A group of healthy individuals acted as baseline for thromboelastometry parameters. RESULTS: Fifty-six cases (mean age, 64±15 years; male/female, 37/19) and 56 controls (mean age, 76±11 years; male/female, 35/21) were enrolled. Cases and controls exhibited markedly hypercoagulable thromboelastometry profiles vs healthy individuals, mainly characterized by a significantly shorter propagation phase of coagulation (clot formation time) and significantly increased maximum clot firmness (P<.001 for all comparisons). Patients with COVID-19 pneumonia had significantly shorter clot formation time and higher maximum clot firmness (P<.01 and P<.05, respectively, for all comparisons) than did controls. CONCLUSION: Patients admitted to internal medicine wards for COVID-19 pneumonia presented a markedly prothrombotic state, which seems peculiar to COVID-19 rather than pneumonia itself. |
format | Online Article Text |
id | pubmed-7528900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-75289002020-10-02 More Severe Hypercoagulable State in Acute COVID-19 Pneumonia as Compared With Other Pneumonia Spiezia, Luca Campello, Elena Cola, Marco Poletto, Francesco Cerruti, Lorenzo Poretto, Anna Simion, Chiara Cattelan, Annamaria Vettor, Roberto Simioni, Paolo Mayo Clin Proc Innov Qual Outcomes Original Article OBJECTIVE: To conduct a comprehensive evaluation of coagulation profiles—via traditional and whole blood thromboelastometry tests—in coronavirus disease 2019 (COVID-19)–positive vs COVID-19–negative patients admitted to medical wards for acute pneumonia. PATIENTS AND METHODS: We enrolled all consecutive patients admitted to internal medicine wards of Padova University Hospital between 7 March and 30 April, 2020, for COVID-19–related pneumonia (cases) vs non–COVID-19 pneumonia (controls). A group of healthy individuals acted as baseline for thromboelastometry parameters. RESULTS: Fifty-six cases (mean age, 64±15 years; male/female, 37/19) and 56 controls (mean age, 76±11 years; male/female, 35/21) were enrolled. Cases and controls exhibited markedly hypercoagulable thromboelastometry profiles vs healthy individuals, mainly characterized by a significantly shorter propagation phase of coagulation (clot formation time) and significantly increased maximum clot firmness (P<.001 for all comparisons). Patients with COVID-19 pneumonia had significantly shorter clot formation time and higher maximum clot firmness (P<.01 and P<.05, respectively, for all comparisons) than did controls. CONCLUSION: Patients admitted to internal medicine wards for COVID-19 pneumonia presented a markedly prothrombotic state, which seems peculiar to COVID-19 rather than pneumonia itself. Elsevier 2020-10-01 /pmc/articles/PMC7528900/ /pubmed/33024937 http://dx.doi.org/10.1016/j.mayocpiqo.2020.09.002 Text en © 2020 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Spiezia, Luca Campello, Elena Cola, Marco Poletto, Francesco Cerruti, Lorenzo Poretto, Anna Simion, Chiara Cattelan, Annamaria Vettor, Roberto Simioni, Paolo More Severe Hypercoagulable State in Acute COVID-19 Pneumonia as Compared With Other Pneumonia |
title | More Severe Hypercoagulable State in Acute COVID-19 Pneumonia as Compared With Other Pneumonia |
title_full | More Severe Hypercoagulable State in Acute COVID-19 Pneumonia as Compared With Other Pneumonia |
title_fullStr | More Severe Hypercoagulable State in Acute COVID-19 Pneumonia as Compared With Other Pneumonia |
title_full_unstemmed | More Severe Hypercoagulable State in Acute COVID-19 Pneumonia as Compared With Other Pneumonia |
title_short | More Severe Hypercoagulable State in Acute COVID-19 Pneumonia as Compared With Other Pneumonia |
title_sort | more severe hypercoagulable state in acute covid-19 pneumonia as compared with other pneumonia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528900/ https://www.ncbi.nlm.nih.gov/pubmed/33024937 http://dx.doi.org/10.1016/j.mayocpiqo.2020.09.002 |
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