Cargando…
Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms
BACKGROUND: Patients with COVID-19 most commonly report respiratory symptoms, with a minority reporting gastrointestinal (GI) symptoms in currently available reports. Additionally, little is known about the symptoms of anosmia/hyposmia, ageusia, and dysgeusia anecdotally seen in COVID-19 patients, w...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528941/ https://www.ncbi.nlm.nih.gov/pubmed/33024695 http://dx.doi.org/10.1016/j.idcr.2020.e00975 |
_version_ | 1783589351471448064 |
---|---|
author | Ho, Bethany E. Ho, Andrea P. Ho, Michaela A. Ho, Elizabeth C. |
author_facet | Ho, Bethany E. Ho, Andrea P. Ho, Michaela A. Ho, Elizabeth C. |
author_sort | Ho, Bethany E. |
collection | PubMed |
description | BACKGROUND: Patients with COVID-19 most commonly report respiratory symptoms, with a minority reporting gastrointestinal (GI) symptoms in currently available reports. Additionally, little is known about the symptoms of anosmia/hyposmia, ageusia, and dysgeusia anecdotally seen in COVID-19 patients, which may potentially be considered both GI and sensory/neurological manifestations of infection. We hope to clarify the prevalence of these symptoms and patterns of transmission within a family cluster. CASE PRESENTATION: We interviewed 7 patients via oral inquiries and a questionnaire, collecting data on subject symptoms and their durations. Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to confirm 2 of these cases. We report a familial cluster of 5 presumed and 2 confirmed COVID-19 cases, all of whom reported one or more GI symptoms and 5 of whom reported sensory symptoms of anosmia/hyposmia, ageusia/hypogeusia, and/or dysgeusia. CONCLUSIONS: This frequency of GI symptoms is high relative to currently available epidemiological reports, which also infrequently report on sensory symptoms. COVID-19 exhibits wide variation in duration, severity, and progression of symptoms, even within a familial cluster. |
format | Online Article Text |
id | pubmed-7528941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-75289412020-10-02 Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms Ho, Bethany E. Ho, Andrea P. Ho, Michaela A. Ho, Elizabeth C. IDCases Case Report BACKGROUND: Patients with COVID-19 most commonly report respiratory symptoms, with a minority reporting gastrointestinal (GI) symptoms in currently available reports. Additionally, little is known about the symptoms of anosmia/hyposmia, ageusia, and dysgeusia anecdotally seen in COVID-19 patients, which may potentially be considered both GI and sensory/neurological manifestations of infection. We hope to clarify the prevalence of these symptoms and patterns of transmission within a family cluster. CASE PRESENTATION: We interviewed 7 patients via oral inquiries and a questionnaire, collecting data on subject symptoms and their durations. Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to confirm 2 of these cases. We report a familial cluster of 5 presumed and 2 confirmed COVID-19 cases, all of whom reported one or more GI symptoms and 5 of whom reported sensory symptoms of anosmia/hyposmia, ageusia/hypogeusia, and/or dysgeusia. CONCLUSIONS: This frequency of GI symptoms is high relative to currently available epidemiological reports, which also infrequently report on sensory symptoms. COVID-19 exhibits wide variation in duration, severity, and progression of symptoms, even within a familial cluster. Elsevier 2020-10-01 /pmc/articles/PMC7528941/ /pubmed/33024695 http://dx.doi.org/10.1016/j.idcr.2020.e00975 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Ho, Bethany E. Ho, Andrea P. Ho, Michaela A. Ho, Elizabeth C. Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms |
title | Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms |
title_full | Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms |
title_fullStr | Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms |
title_full_unstemmed | Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms |
title_short | Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms |
title_sort | case report of familial covid-19 cluster associated with high prevalence of anosmia, ageusia, and gastrointestinal symptoms |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528941/ https://www.ncbi.nlm.nih.gov/pubmed/33024695 http://dx.doi.org/10.1016/j.idcr.2020.e00975 |
work_keys_str_mv | AT hobethanye casereportoffamilialcovid19clusterassociatedwithhighprevalenceofanosmiaageusiaandgastrointestinalsymptoms AT hoandreap casereportoffamilialcovid19clusterassociatedwithhighprevalenceofanosmiaageusiaandgastrointestinalsymptoms AT homichaelaa casereportoffamilialcovid19clusterassociatedwithhighprevalenceofanosmiaageusiaandgastrointestinalsymptoms AT hoelizabethc casereportoffamilialcovid19clusterassociatedwithhighprevalenceofanosmiaageusiaandgastrointestinalsymptoms |