Are diabetes and its medications risk factors for the development of COVID-19? Data from a population-based study in Sicily

BACKGROUND AND AIMS: Diabetes mellitus (DM) has been associated with higher incidence of severe cases of COVID-19 in hospitalized patients, but it is unknown whether DM is a risk factor for the overall COVID-19 incidence. The aim of present study was to investigate whether there is an association of...

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Detalles Bibliográficos
Autores principales: Silverii, G. Antonio, Monami, Matteo, Cernigliaro, Achille, Vigneri, Enrica, Guarnotta, Valentina, Scondotto, Salvatore, Allotta, Vincenza A., Conti, Michela, Giordano, Carla, Mannucci, Edoardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528967/
https://www.ncbi.nlm.nih.gov/pubmed/33223405
http://dx.doi.org/10.1016/j.numecd.2020.09.028
Descripción
Sumario:BACKGROUND AND AIMS: Diabetes mellitus (DM) has been associated with higher incidence of severe cases of COVID-19 in hospitalized patients, but it is unknown whether DM is a risk factor for the overall COVID-19 incidence. The aim of present study was to investigate whether there is an association of DM with COVID-19 prevalence and case fatality, and between different DM medications and risk for COVID-19 infection and death. METHODS AND RESULTS: retrospective observational study on all SARS-CoV-2 positive (SARS-CoV-2(+)) cases and deaths in Sicily up to 2020, May 14th. No difference in COVID-19 prevalence was found between people with and without DM (RR 0.92 [0.79–1.09]). Case fatality was significantly higher in SARS-CoV-2(+) with DM (RR 4.5 [3.55–5.71]). No diabetes medication was associated with differences in risk for SARS-Cov2 infection. CONCLUSIONS: in Sicily, DM was not a risk factor for COVID-19 infection, whereas it was associated with a higher case fatality.

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