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Benign Feminizing Adrenal Tumor in an Adult Male
Background: Feminizing adrenal tumors are rare and generally malignant tumors usually seen in male adults and children. We report the case of a benign feminizing adrenal tumor in a male patient. To our knowledge, only 2 other cases of benign, estrogen-only–secreting adrenal tumors have been reported...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Division of Ochsner Clinic Foundation
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529132/ https://www.ncbi.nlm.nih.gov/pubmed/33071666 http://dx.doi.org/10.31486/toj.19.0031 |
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author | Ahmad, Raza M. Ingram, Kyle Corsetti, Ralph |
author_facet | Ahmad, Raza M. Ingram, Kyle Corsetti, Ralph |
author_sort | Ahmad, Raza M. |
collection | PubMed |
description | Background: Feminizing adrenal tumors are rare and generally malignant tumors usually seen in male adults and children. We report the case of a benign feminizing adrenal tumor in a male patient. To our knowledge, only 2 other cases of benign, estrogen-only–secreting adrenal tumors have been reported. Case Report: A 44-year-old male with a history of hypertension presented to his primary care physician with chest tenderness, fatigue, and erectile dysfunction. Hormonal workup and imaging identified an estrogen-only–secreting adrenal adenoma. The adenoma was removed via laparoscopic adrenalectomy, and the patient had a normal postoperative course. Pathologic findings were an adrenal cortical adenoma with a Weiss score of 0 and a Ki-67 score of 0%. At 6-month follow-up, the patient's symptoms had significantly improved, and his previously abnormal sex hormone levels were within normal limits. Conclusion: Given the ambiguity in distinguishing between malignant and benign feminizing adrenal tumors, we suggest that radiologic (via Hounsfield units), clinical (via trending hormone levels), and histopathologic (via Weiss and Ki-67 scores) findings are sufficient to confirm the benign nature of this commonly malignant tumor. |
format | Online Article Text |
id | pubmed-7529132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Academic Division of Ochsner Clinic Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-75291322020-10-15 Benign Feminizing Adrenal Tumor in an Adult Male Ahmad, Raza M. Ingram, Kyle Corsetti, Ralph Ochsner J Case Reports and Clinical Observations Background: Feminizing adrenal tumors are rare and generally malignant tumors usually seen in male adults and children. We report the case of a benign feminizing adrenal tumor in a male patient. To our knowledge, only 2 other cases of benign, estrogen-only–secreting adrenal tumors have been reported. Case Report: A 44-year-old male with a history of hypertension presented to his primary care physician with chest tenderness, fatigue, and erectile dysfunction. Hormonal workup and imaging identified an estrogen-only–secreting adrenal adenoma. The adenoma was removed via laparoscopic adrenalectomy, and the patient had a normal postoperative course. Pathologic findings were an adrenal cortical adenoma with a Weiss score of 0 and a Ki-67 score of 0%. At 6-month follow-up, the patient's symptoms had significantly improved, and his previously abnormal sex hormone levels were within normal limits. Conclusion: Given the ambiguity in distinguishing between malignant and benign feminizing adrenal tumors, we suggest that radiologic (via Hounsfield units), clinical (via trending hormone levels), and histopathologic (via Weiss and Ki-67 scores) findings are sufficient to confirm the benign nature of this commonly malignant tumor. Academic Division of Ochsner Clinic Foundation 2020 2020 /pmc/articles/PMC7529132/ /pubmed/33071666 http://dx.doi.org/10.31486/toj.19.0031 Text en ©2020 by the author(s); Creative Commons Attribution License (CC BY) http://creativecommons.org/licenses/by/4.0/legalcode ©2020 by the author(s); licensee Ochsner Journal, Ochsner Clinic Foundation, New Orleans, LA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (creativecommons.org/licenses/by/4.0/legalcode) that permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Case Reports and Clinical Observations Ahmad, Raza M. Ingram, Kyle Corsetti, Ralph Benign Feminizing Adrenal Tumor in an Adult Male |
title | Benign Feminizing Adrenal Tumor in an Adult Male |
title_full | Benign Feminizing Adrenal Tumor in an Adult Male |
title_fullStr | Benign Feminizing Adrenal Tumor in an Adult Male |
title_full_unstemmed | Benign Feminizing Adrenal Tumor in an Adult Male |
title_short | Benign Feminizing Adrenal Tumor in an Adult Male |
title_sort | benign feminizing adrenal tumor in an adult male |
topic | Case Reports and Clinical Observations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529132/ https://www.ncbi.nlm.nih.gov/pubmed/33071666 http://dx.doi.org/10.31486/toj.19.0031 |
work_keys_str_mv | AT ahmadrazam benignfeminizingadrenaltumorinanadultmale AT ingramkyle benignfeminizingadrenaltumorinanadultmale AT corsettiralph benignfeminizingadrenaltumorinanadultmale |