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Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice

In spite of the widespread use of electronic cigarettes, also known as e-cigarettes, and the proposed adverse cardiac effects of nicotine, the detrimental effects of e-cigarettes on the heart are not well known. This study examines the detrimental effects of e-cigarettes with nicotine at doses that...

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Autores principales: Hasan, Kamrul M., Friedman, Theodore C., Parveen, Meher, Espinoza-Derout, Jorge, Bautista, Francisco, Razipour, Mohammad M., Shao, Xuesi M., Jordan, Maria C., Roos, Kenneth P., Mahata, Sushil K., Sinha-Hikim, Amiya P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529198/
https://www.ncbi.nlm.nih.gov/pubmed/33002059
http://dx.doi.org/10.1371/journal.pone.0239671
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author Hasan, Kamrul M.
Friedman, Theodore C.
Parveen, Meher
Espinoza-Derout, Jorge
Bautista, Francisco
Razipour, Mohammad M.
Shao, Xuesi M.
Jordan, Maria C.
Roos, Kenneth P.
Mahata, Sushil K.
Sinha-Hikim, Amiya P.
author_facet Hasan, Kamrul M.
Friedman, Theodore C.
Parveen, Meher
Espinoza-Derout, Jorge
Bautista, Francisco
Razipour, Mohammad M.
Shao, Xuesi M.
Jordan, Maria C.
Roos, Kenneth P.
Mahata, Sushil K.
Sinha-Hikim, Amiya P.
author_sort Hasan, Kamrul M.
collection PubMed
description In spite of the widespread use of electronic cigarettes, also known as e-cigarettes, and the proposed adverse cardiac effects of nicotine, the detrimental effects of e-cigarettes on the heart are not well known. This study examines the detrimental effects of e-cigarettes with nicotine at doses that yield circulating nicotine and cotinine in the ranges similar to the levels found in habitual smokers, and a high fat diet (HFD) on cardiac structure and function in a commonly used model of diet-induced obesity (DIO). C57BL/6J mice on an HFD were exposed to e-cigarette in the presence (2.4% nicotine) or absence (0% nicotine) of nicotine and saline aerosol for 12 weeks. Echocardiographic data demonstrated a decrease in left ventricular (LV) fractional shortening, LV ejection fraction, and velocity of circumferential fiber shortening (VCF) in mice treated with e-cigarette (2.4% nicotine) compared to e-cigarette (0% nicotine) or saline exposed mice. Cardiomyocytes (CMs) of mice treated with e-cigarette (2.4% nicotine) exhibited LV abnormalities, including lipid accumulation (ventricular steatosis), myofibrillar derangement and destruction, and mitochondrial hypertrophy, as revealed by transmission electron microscopy. The detrimental effects of e-cigarettes (2.4% nicotine) on cardiac structure and function was accompanied by increased oxidative stress, plasma free fatty acid levels, CM apoptosis, and inactivation of AMP-activated protein kinase and activation of its downstream target, acetyl-CoA-carboxylase. Our results indicate profound adverse effects of e-cigarettes (2.4% nicotine) on the heart in obese mice and raise questions about the safety of the nicotine e-cigarettes use.
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spelling pubmed-75291982020-10-02 Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice Hasan, Kamrul M. Friedman, Theodore C. Parveen, Meher Espinoza-Derout, Jorge Bautista, Francisco Razipour, Mohammad M. Shao, Xuesi M. Jordan, Maria C. Roos, Kenneth P. Mahata, Sushil K. Sinha-Hikim, Amiya P. PLoS One Research Article In spite of the widespread use of electronic cigarettes, also known as e-cigarettes, and the proposed adverse cardiac effects of nicotine, the detrimental effects of e-cigarettes on the heart are not well known. This study examines the detrimental effects of e-cigarettes with nicotine at doses that yield circulating nicotine and cotinine in the ranges similar to the levels found in habitual smokers, and a high fat diet (HFD) on cardiac structure and function in a commonly used model of diet-induced obesity (DIO). C57BL/6J mice on an HFD were exposed to e-cigarette in the presence (2.4% nicotine) or absence (0% nicotine) of nicotine and saline aerosol for 12 weeks. Echocardiographic data demonstrated a decrease in left ventricular (LV) fractional shortening, LV ejection fraction, and velocity of circumferential fiber shortening (VCF) in mice treated with e-cigarette (2.4% nicotine) compared to e-cigarette (0% nicotine) or saline exposed mice. Cardiomyocytes (CMs) of mice treated with e-cigarette (2.4% nicotine) exhibited LV abnormalities, including lipid accumulation (ventricular steatosis), myofibrillar derangement and destruction, and mitochondrial hypertrophy, as revealed by transmission electron microscopy. The detrimental effects of e-cigarettes (2.4% nicotine) on cardiac structure and function was accompanied by increased oxidative stress, plasma free fatty acid levels, CM apoptosis, and inactivation of AMP-activated protein kinase and activation of its downstream target, acetyl-CoA-carboxylase. Our results indicate profound adverse effects of e-cigarettes (2.4% nicotine) on the heart in obese mice and raise questions about the safety of the nicotine e-cigarettes use. Public Library of Science 2020-10-01 /pmc/articles/PMC7529198/ /pubmed/33002059 http://dx.doi.org/10.1371/journal.pone.0239671 Text en © 2020 Hasan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hasan, Kamrul M.
Friedman, Theodore C.
Parveen, Meher
Espinoza-Derout, Jorge
Bautista, Francisco
Razipour, Mohammad M.
Shao, Xuesi M.
Jordan, Maria C.
Roos, Kenneth P.
Mahata, Sushil K.
Sinha-Hikim, Amiya P.
Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice
title Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice
title_full Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice
title_fullStr Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice
title_full_unstemmed Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice
title_short Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice
title_sort electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529198/
https://www.ncbi.nlm.nih.gov/pubmed/33002059
http://dx.doi.org/10.1371/journal.pone.0239671
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