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18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey

INTRODUCTION: Population-based HIV-free survival at 18–24 months of age among HIV-exposed infants in high prevalence settings in the era of treatment for all is largely unknown. We conducted a community-based survey to determine outcomes of HIV-exposed infants at 18–24 months in Lesotho. METHODS: Be...

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Autores principales: Tiam, Appolinaire, Gill, Michelle M., Machekano, Rhoderick, Tukei, Vincent, Mokone, Majoalane, Viana, Shannon, Letsie, Mosilinyane, Tsietso, Mots’oane, Seipati, Irene, Khachane, Cecilia, Nei, Marethabile, Mohai, Florence, Tylleskär, Thorkild, Guay, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529246/
https://www.ncbi.nlm.nih.gov/pubmed/33002002
http://dx.doi.org/10.1371/journal.pone.0237409
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author Tiam, Appolinaire
Gill, Michelle M.
Machekano, Rhoderick
Tukei, Vincent
Mokone, Majoalane
Viana, Shannon
Letsie, Mosilinyane
Tsietso, Mots’oane
Seipati, Irene
Khachane, Cecilia
Nei, Marethabile
Mohai, Florence
Tylleskär, Thorkild
Guay, Laura
author_facet Tiam, Appolinaire
Gill, Michelle M.
Machekano, Rhoderick
Tukei, Vincent
Mokone, Majoalane
Viana, Shannon
Letsie, Mosilinyane
Tsietso, Mots’oane
Seipati, Irene
Khachane, Cecilia
Nei, Marethabile
Mohai, Florence
Tylleskär, Thorkild
Guay, Laura
author_sort Tiam, Appolinaire
collection PubMed
description INTRODUCTION: Population-based HIV-free survival at 18–24 months of age among HIV-exposed infants in high prevalence settings in the era of treatment for all is largely unknown. We conducted a community-based survey to determine outcomes of HIV-exposed infants at 18–24 months in Lesotho. METHODS: Between November 2015 and December 2016, we conducted a survey among households with a child born 18–24 months prior to data collection. Catchment areas from 25 health facilities in Butha-Buthe, Maseru, Mohale’s Hoek and Thaba-Tseka districts were randomly selected using probability proportional to size sampling. Consecutive households were visited and eligible consenting caregivers and children were enrolled. Rapid HIV antibody testing was performed on mothers of unknown HIV status (never tested or tested HIV-negative >3 months prior) and their children, and to children born to known HIV-positive mothers. Information on demographics, health-seeking behavior, HIV, and mortality were captured for mothers and children, including those who died. The difference in survival between subgroups was determined using the log-rank test. RESULTS: Of the 1,852 mothers/caregivers enrolled, 570 mothers were HIV-positive. The mother-to-child HIV transmission rate was 5.7% [95% CI: 4.0–8.0]. The mortality rate was 2.6% [95% CI: 1.6–4.2] among HIV-exposed children compared to 1.4% (95% CI: 0.9–2.3) among HIV-unexposed children. HIV-free survival was 91.8% [95% CI: 89.2–93.8] among HIV-exposed infants. Disclosure of mother’s HIV status (aOR = 4.9, 95% CI: 1.3–18.2) and initiation of cotrimoxazole prophylaxis in the child (aOR = 3.9, 95% CI: 1.2–12.6) were independently associated with increased HIV-free survival while child growth problems (aOR = 0.2, 95% CI: 0.09–0.5) were independently associated with reduced HIV-free survival. CONCLUSION: Even in the context of lifelong antiretroviral therapy among pregnant and breastfeeding women, HIV has a significant effect on survival among HIV-exposed children compared to unexposed children. Lesotho has not reached elimination of HIV transmission from mother to child.
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spelling pubmed-75292462020-10-02 18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey Tiam, Appolinaire Gill, Michelle M. Machekano, Rhoderick Tukei, Vincent Mokone, Majoalane Viana, Shannon Letsie, Mosilinyane Tsietso, Mots’oane Seipati, Irene Khachane, Cecilia Nei, Marethabile Mohai, Florence Tylleskär, Thorkild Guay, Laura PLoS One Research Article INTRODUCTION: Population-based HIV-free survival at 18–24 months of age among HIV-exposed infants in high prevalence settings in the era of treatment for all is largely unknown. We conducted a community-based survey to determine outcomes of HIV-exposed infants at 18–24 months in Lesotho. METHODS: Between November 2015 and December 2016, we conducted a survey among households with a child born 18–24 months prior to data collection. Catchment areas from 25 health facilities in Butha-Buthe, Maseru, Mohale’s Hoek and Thaba-Tseka districts were randomly selected using probability proportional to size sampling. Consecutive households were visited and eligible consenting caregivers and children were enrolled. Rapid HIV antibody testing was performed on mothers of unknown HIV status (never tested or tested HIV-negative >3 months prior) and their children, and to children born to known HIV-positive mothers. Information on demographics, health-seeking behavior, HIV, and mortality were captured for mothers and children, including those who died. The difference in survival between subgroups was determined using the log-rank test. RESULTS: Of the 1,852 mothers/caregivers enrolled, 570 mothers were HIV-positive. The mother-to-child HIV transmission rate was 5.7% [95% CI: 4.0–8.0]. The mortality rate was 2.6% [95% CI: 1.6–4.2] among HIV-exposed children compared to 1.4% (95% CI: 0.9–2.3) among HIV-unexposed children. HIV-free survival was 91.8% [95% CI: 89.2–93.8] among HIV-exposed infants. Disclosure of mother’s HIV status (aOR = 4.9, 95% CI: 1.3–18.2) and initiation of cotrimoxazole prophylaxis in the child (aOR = 3.9, 95% CI: 1.2–12.6) were independently associated with increased HIV-free survival while child growth problems (aOR = 0.2, 95% CI: 0.09–0.5) were independently associated with reduced HIV-free survival. CONCLUSION: Even in the context of lifelong antiretroviral therapy among pregnant and breastfeeding women, HIV has a significant effect on survival among HIV-exposed children compared to unexposed children. Lesotho has not reached elimination of HIV transmission from mother to child. Public Library of Science 2020-10-01 /pmc/articles/PMC7529246/ /pubmed/33002002 http://dx.doi.org/10.1371/journal.pone.0237409 Text en © 2020 Tiam et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tiam, Appolinaire
Gill, Michelle M.
Machekano, Rhoderick
Tukei, Vincent
Mokone, Majoalane
Viana, Shannon
Letsie, Mosilinyane
Tsietso, Mots’oane
Seipati, Irene
Khachane, Cecilia
Nei, Marethabile
Mohai, Florence
Tylleskär, Thorkild
Guay, Laura
18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey
title 18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey
title_full 18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey
title_fullStr 18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey
title_full_unstemmed 18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey
title_short 18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey
title_sort 18-24-month hiv-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: results of a community-based survey
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529246/
https://www.ncbi.nlm.nih.gov/pubmed/33002002
http://dx.doi.org/10.1371/journal.pone.0237409
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