Mitochondrial bioenergetic dysfunction in the D2.mdx model of Duchenne muscular dystrophy is associated with microtubule disorganization in skeletal muscle

In Duchenne muscular dystrophy, a lack of dystrophin leads to extensive muscle weakness and atrophy that is linked to cellular metabolic dysfunction and oxidative stress. This dystrophinopathy results in a loss of tethering between microtubules and the sarcolemma. Microtubules are also believed to r...

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Detalles Bibliográficos
Autores principales: Ramos, Sofhia V., Hughes, Meghan C., Delfinis, Luca J., Bellissimo, Catherine A., Perry, Christopher G. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529311/
https://www.ncbi.nlm.nih.gov/pubmed/33002037
http://dx.doi.org/10.1371/journal.pone.0237138

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