Impairment of nuclear F-actin formation and its relevance to cellular phenotypes in Hutchinson-Gilford progeria syndrome

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation of lamin A, which contributes to nuclear architecture and the spatial organization of chromatin in the nucleus. The expression of a lamin A mutant, named progerin, leads to functional and structural disrup...

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Detalles Bibliográficos
Autores principales: Takahashi, Yuto, Hiratsuka, Shogo, Machida, Nanako, Takahashi, Daisuke, Matsushita, Junpei, Hozak, Pavel, Misteli, Tom, Miyamoto, Kei, Harata, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529414/
https://www.ncbi.nlm.nih.gov/pubmed/32954953
http://dx.doi.org/10.1080/19491034.2020.1815395

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