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Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells
The nuclear lamina is a meshwork of intermediate filament proteins, and lamin A is the primary mechanical protein. An altered splicing of lamin A, known as progerin, causes the disease Hutchinson-Gilford progeria syndrome. Progerin-expressing cells have altered nuclear shapes and stiffened nuclear l...
Autores principales: | Danielsson, Brooke E., Tieu, Katie V., Bathula, Kranthidhar, Armiger, Travis J., Vellala, Pragna S., Taylor, Rebecca E., Dahl, Kris Noel, Conway, Daniel E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529416/ https://www.ncbi.nlm.nih.gov/pubmed/32816594 http://dx.doi.org/10.1080/19491034.2020.1802906 |
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