IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation

Notch signaling regulates squamous cell proliferation and differentiation and is frequently disrupted in squamous cell carcinomas, in which Notch is tumor suppressive. Here, we show that conditional activation of Notch in squamous cells activates a context-specific gene expression program through li...

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Detalles Bibliográficos
Autores principales: Pan, Li, Lemieux, Madeleine E, Thomas, Tom, Rogers, Julia M, Lipper, Colin H, Lee, Winston, Johnson, Carl, Sholl, Lynette M, South, Andrew P, Marto, Jarrod A, Adelmant, Guillaume O, Blacklow, Stephen C, Aster, Jon C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529455/
https://www.ncbi.nlm.nih.gov/pubmed/32936072
http://dx.doi.org/10.7554/eLife.58081

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