Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report

Metastasis of extra-intestinal carcinoma to the gastrointestinal tract (GIT) is a rare event, most commonly occurring with malignant melanoma. Anti-PD-1 (programmed death-1) immunotherapeutic agents are immune checkpoint inhibitors with proven benefit across multiple cancer types, including squamous...

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Autores principales: Dabek, Robert J, Bizanti, Anas, Thomas, Samantha, Kalla, Abhishek, Hamdallah, Isam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
General Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529493/
https://www.ncbi.nlm.nih.gov/pubmed/33029471
http://dx.doi.org/10.7759/cureus.10739
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author Dabek, Robert J
Bizanti, Anas
Thomas, Samantha
Kalla, Abhishek
Hamdallah, Isam
author_facet Dabek, Robert J
Bizanti, Anas
Thomas, Samantha
Kalla, Abhishek
Hamdallah, Isam
author_sort Dabek, Robert J
collection PubMed
description Metastasis of extra-intestinal carcinoma to the gastrointestinal tract (GIT) is a rare event, most commonly occurring with malignant melanoma. Anti-PD-1 (programmed death-1) immunotherapeutic agents are immune checkpoint inhibitors with proven benefit across multiple cancer types, including squamous cell carcinoma of the head and neck (SCCHN). Here we describe a case of small bowel perforation attributed to a primary SCCHN metastasizing to the GIT in the setting of treatment with PD-1 inhibitors.
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spelling pubmed-75294932020-10-06 Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report Dabek, Robert J Bizanti, Anas Thomas, Samantha Kalla, Abhishek Hamdallah, Isam Cureus General Surgery Metastasis of extra-intestinal carcinoma to the gastrointestinal tract (GIT) is a rare event, most commonly occurring with malignant melanoma. Anti-PD-1 (programmed death-1) immunotherapeutic agents are immune checkpoint inhibitors with proven benefit across multiple cancer types, including squamous cell carcinoma of the head and neck (SCCHN). Here we describe a case of small bowel perforation attributed to a primary SCCHN metastasizing to the GIT in the setting of treatment with PD-1 inhibitors. Cureus 2020-09-30 /pmc/articles/PMC7529493/ /pubmed/33029471 http://dx.doi.org/10.7759/cureus.10739 Text en Copyright © 2020, Dabek et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle General Surgery
Dabek, Robert J
Bizanti, Anas
Thomas, Samantha
Kalla, Abhishek
Hamdallah, Isam
Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report
title Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report
title_full Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report
title_fullStr Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report
title_full_unstemmed Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report
title_short Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report
title_sort squamous cell carcinoma of the tonsil causing small bowel perforation in the setting of metastasis and treatment with programmed death-1 inhibitors: a case report
topic General Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529493/
https://www.ncbi.nlm.nih.gov/pubmed/33029471
http://dx.doi.org/10.7759/cureus.10739
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