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Atypical Vascular Proliferation Secondary to Radiotherapy in a Patient With a History of Synovial Sarcoma

We present the case of a 21-year-old male patient with a history of monophasic synovial sarcoma in his left thigh, which was treated with surgical resection, radiotherapy, and chemotherapy with mesna, doxorubicin, and Ifosfamide (MAI protocol). Approximately six years after the end of the oncologica...

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Autores principales: Bonilla, Carlos E, Perez Lugo, Lucy M, Vallejo Yepes, Camilo, Osma Charris, Handerson R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529495/
https://www.ncbi.nlm.nih.gov/pubmed/33029459
http://dx.doi.org/10.7759/cureus.10179
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author Bonilla, Carlos E
Perez Lugo, Lucy M
Vallejo Yepes, Camilo
Osma Charris, Handerson R
author_facet Bonilla, Carlos E
Perez Lugo, Lucy M
Vallejo Yepes, Camilo
Osma Charris, Handerson R
author_sort Bonilla, Carlos E
collection PubMed
description We present the case of a 21-year-old male patient with a history of monophasic synovial sarcoma in his left thigh, which was treated with surgical resection, radiotherapy, and chemotherapy with mesna, doxorubicin, and Ifosfamide (MAI protocol). Approximately six years after the end of the oncological treatment, he presented a nodular, polypoid lesion in the left popliteal region, which was painless and fast growing. Ultimately, the biopsy was consistent with atypical vascular proliferation (AVP). Vascular lesions after radiotherapy include a wide spectrum of pathologies that range from benign lesions such as AVP to malignant ones with very poor prognosis such as angiosarcoma, the distinction between one and the other can be difficult, being the determination rearrangement or amplification of gene c-myc, a key to make an accurate diagnosis in case of doubt.
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spelling pubmed-75294952020-10-06 Atypical Vascular Proliferation Secondary to Radiotherapy in a Patient With a History of Synovial Sarcoma Bonilla, Carlos E Perez Lugo, Lucy M Vallejo Yepes, Camilo Osma Charris, Handerson R Cureus Dermatology We present the case of a 21-year-old male patient with a history of monophasic synovial sarcoma in his left thigh, which was treated with surgical resection, radiotherapy, and chemotherapy with mesna, doxorubicin, and Ifosfamide (MAI protocol). Approximately six years after the end of the oncological treatment, he presented a nodular, polypoid lesion in the left popliteal region, which was painless and fast growing. Ultimately, the biopsy was consistent with atypical vascular proliferation (AVP). Vascular lesions after radiotherapy include a wide spectrum of pathologies that range from benign lesions such as AVP to malignant ones with very poor prognosis such as angiosarcoma, the distinction between one and the other can be difficult, being the determination rearrangement or amplification of gene c-myc, a key to make an accurate diagnosis in case of doubt. Cureus 2020-09-01 /pmc/articles/PMC7529495/ /pubmed/33029459 http://dx.doi.org/10.7759/cureus.10179 Text en Copyright © 2020, Bonilla et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Bonilla, Carlos E
Perez Lugo, Lucy M
Vallejo Yepes, Camilo
Osma Charris, Handerson R
Atypical Vascular Proliferation Secondary to Radiotherapy in a Patient With a History of Synovial Sarcoma
title Atypical Vascular Proliferation Secondary to Radiotherapy in a Patient With a History of Synovial Sarcoma
title_full Atypical Vascular Proliferation Secondary to Radiotherapy in a Patient With a History of Synovial Sarcoma
title_fullStr Atypical Vascular Proliferation Secondary to Radiotherapy in a Patient With a History of Synovial Sarcoma
title_full_unstemmed Atypical Vascular Proliferation Secondary to Radiotherapy in a Patient With a History of Synovial Sarcoma
title_short Atypical Vascular Proliferation Secondary to Radiotherapy in a Patient With a History of Synovial Sarcoma
title_sort atypical vascular proliferation secondary to radiotherapy in a patient with a history of synovial sarcoma
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529495/
https://www.ncbi.nlm.nih.gov/pubmed/33029459
http://dx.doi.org/10.7759/cureus.10179
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