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The role of ubiquitination and deubiquitination in cancer metabolism

Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of cancer, sustaining cancer cell growth. Multiple signaling pathways, transcription factors and metabolic enzymes participate in the...

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Autores principales: Sun, Tianshui, Liu, Zhuonan, Yang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529510/
https://www.ncbi.nlm.nih.gov/pubmed/33004065
http://dx.doi.org/10.1186/s12943-020-01262-x
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author Sun, Tianshui
Liu, Zhuonan
Yang, Qing
author_facet Sun, Tianshui
Liu, Zhuonan
Yang, Qing
author_sort Sun, Tianshui
collection PubMed
description Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of cancer, sustaining cancer cell growth. Multiple signaling pathways, transcription factors and metabolic enzymes participate in the modulation of cancer metabolism and thus, metabolic reprogramming is a highly complex process. Recent studies have observed that ubiquitination and deubiquitination are involved in the regulation of metabolic reprogramming in cancer cells. As one of the most important type of post-translational modifications, ubiquitination is a multistep enzymatic process, involved in diverse cellular biological activities. Dysregulation of ubiquitination and deubiquitination contributes to various disease, including cancer. Here, we discuss the role of ubiquitination and deubiquitination in the regulation of cancer metabolism, which is aimed at highlighting the importance of this post-translational modification in metabolic reprogramming and supporting the development of new therapeutic approaches for cancer treatment.
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spelling pubmed-75295102020-10-02 The role of ubiquitination and deubiquitination in cancer metabolism Sun, Tianshui Liu, Zhuonan Yang, Qing Mol Cancer Review Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of cancer, sustaining cancer cell growth. Multiple signaling pathways, transcription factors and metabolic enzymes participate in the modulation of cancer metabolism and thus, metabolic reprogramming is a highly complex process. Recent studies have observed that ubiquitination and deubiquitination are involved in the regulation of metabolic reprogramming in cancer cells. As one of the most important type of post-translational modifications, ubiquitination is a multistep enzymatic process, involved in diverse cellular biological activities. Dysregulation of ubiquitination and deubiquitination contributes to various disease, including cancer. Here, we discuss the role of ubiquitination and deubiquitination in the regulation of cancer metabolism, which is aimed at highlighting the importance of this post-translational modification in metabolic reprogramming and supporting the development of new therapeutic approaches for cancer treatment. BioMed Central 2020-10-01 /pmc/articles/PMC7529510/ /pubmed/33004065 http://dx.doi.org/10.1186/s12943-020-01262-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Sun, Tianshui
Liu, Zhuonan
Yang, Qing
The role of ubiquitination and deubiquitination in cancer metabolism
title The role of ubiquitination and deubiquitination in cancer metabolism
title_full The role of ubiquitination and deubiquitination in cancer metabolism
title_fullStr The role of ubiquitination and deubiquitination in cancer metabolism
title_full_unstemmed The role of ubiquitination and deubiquitination in cancer metabolism
title_short The role of ubiquitination and deubiquitination in cancer metabolism
title_sort role of ubiquitination and deubiquitination in cancer metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529510/
https://www.ncbi.nlm.nih.gov/pubmed/33004065
http://dx.doi.org/10.1186/s12943-020-01262-x
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