Quantitative multiplex immunofluorescence analysis identifies infiltrating PD1(+)CD8(+) and CD8(+) T cells as predictive of response to neoadjuvant chemotherapy in breast cancer

BACKGROUND: This study aimed to explore the potentially predictive role and dynamic changes of immune checkpoints on T cell subsets in patients with breast cancer receiving neoadjuvant chemotherapies. METHODS: Fluorescent multiplex immunohistochemistry (mIHC) was used to stain CD4, CD8, PD1, TIM3, a...

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Detalles Bibliográficos
Autores principales: Liang, Hongling, Li, Hongsheng, Xie, Zhi, Jin, Tianen, Chen, Yu, Lv, Zhiyi, Tan, Xiaojun, Li, Jia, Han, Guodong, He, Weixing, Qiu, Ni, Jiang, Ming, Zhou, Jie, Xia, Haoming, Zhan, Yongtao, Cui, Lulu, Guo, Weiling, Huang, Jianqing, Zhang, Xuchao, Wu, Yi‐long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529566/
https://www.ncbi.nlm.nih.gov/pubmed/32894006
http://dx.doi.org/10.1111/1759-7714.13639

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