Neurotrophin signalling in amygdala-dependent cued fear learning

The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory are mediated by changes in synaptic strength was shown most convincingly at thalamic and cortical afferents to the lateral amygdala. The neurotrophin br...

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Autores principales: Meis, Susanne, Endres, Thomas, Lessmann, Volkmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529623/
https://www.ncbi.nlm.nih.gov/pubmed/32845430
http://dx.doi.org/10.1007/s00441-020-03260-3
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author Meis, Susanne
Endres, Thomas
Lessmann, Volkmar
author_facet Meis, Susanne
Endres, Thomas
Lessmann, Volkmar
author_sort Meis, Susanne
collection PubMed
description The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory are mediated by changes in synaptic strength was shown most convincingly at thalamic and cortical afferents to the lateral amygdala. The neurotrophin brain-derived neurotrophic factor (BDNF) is known to regulate synaptic plasticity and memory formation in many areas of the mammalian brain including the amygdala, where BDNF signalling via tropomyosin-related kinase B (TrkB) receptors is prominently involved in fear learning. This review updates the current understanding of BDNF/TrkB signalling in the amygdala related to fear learning and extinction. In addition, actions of proBDNF/p75NTR and NGF/TrkA as well as NT-3/TrkC signalling in the amygdala are introduced.
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spelling pubmed-75296232020-10-19 Neurotrophin signalling in amygdala-dependent cued fear learning Meis, Susanne Endres, Thomas Lessmann, Volkmar Cell Tissue Res Review The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory are mediated by changes in synaptic strength was shown most convincingly at thalamic and cortical afferents to the lateral amygdala. The neurotrophin brain-derived neurotrophic factor (BDNF) is known to regulate synaptic plasticity and memory formation in many areas of the mammalian brain including the amygdala, where BDNF signalling via tropomyosin-related kinase B (TrkB) receptors is prominently involved in fear learning. This review updates the current understanding of BDNF/TrkB signalling in the amygdala related to fear learning and extinction. In addition, actions of proBDNF/p75NTR and NGF/TrkA as well as NT-3/TrkC signalling in the amygdala are introduced. Springer Berlin Heidelberg 2020-08-26 2020 /pmc/articles/PMC7529623/ /pubmed/32845430 http://dx.doi.org/10.1007/s00441-020-03260-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Meis, Susanne
Endres, Thomas
Lessmann, Volkmar
Neurotrophin signalling in amygdala-dependent cued fear learning
title Neurotrophin signalling in amygdala-dependent cued fear learning
title_full Neurotrophin signalling in amygdala-dependent cued fear learning
title_fullStr Neurotrophin signalling in amygdala-dependent cued fear learning
title_full_unstemmed Neurotrophin signalling in amygdala-dependent cued fear learning
title_short Neurotrophin signalling in amygdala-dependent cued fear learning
title_sort neurotrophin signalling in amygdala-dependent cued fear learning
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529623/
https://www.ncbi.nlm.nih.gov/pubmed/32845430
http://dx.doi.org/10.1007/s00441-020-03260-3
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