Progressive optic atrophy in a retinal ganglion cell-specific mouse model of complex I deficiency

Optic atrophy resulting from retinal ganglion cell (RGC) degeneration is a prominent ocular manifestation of mitochondrial dysfunction. Although transgenic mice lacking the mitochondrial complex I accessory subunit NDUFS4 develop early-onset optic atrophy, severe systemic mitochondrial dysfunction l...

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Detalles Bibliográficos
Autores principales: Wang, Luyu, Klingeborn, Mikael, Travis, Amanda M., Hao, Ying, Arshavsky, Vadim Y., Gospe, Sidney M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529752/
https://www.ncbi.nlm.nih.gov/pubmed/33004958
http://dx.doi.org/10.1038/s41598-020-73353-0

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