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Biophysical ambiguities prevent accurate genetic prediction
A goal of biology is to predict how mutations combine to alter phenotypes, fitness and disease. It is often assumed that mutations combine additively or with interactions that can be predicted. Here, we show using simulations that, even for the simple example of the lambda phage transcription factor...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529754/ https://www.ncbi.nlm.nih.gov/pubmed/33004824 http://dx.doi.org/10.1038/s41467-020-18694-0 |