Over-activation of a nonessential bacterial protease DegP as an antibiotic strategy

Rising antibiotic resistance urgently begs for novel targets and strategies for antibiotic discovery. Here, we report that over-activation of the periplasmic DegP protease, a member of the highly conserved HtrA family, can be a viable strategy for antibiotic development. We demonstrate that tripodal...

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Detalles Bibliográficos
Autores principales: Cho, Hyunjin, Choi, Yuri, Min, Kyungjin, Son, Jung Bae, Park, Hyojin, Lee, Hyung Ho, Kim, Seokhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529758/
https://www.ncbi.nlm.nih.gov/pubmed/33005001
http://dx.doi.org/10.1038/s42003-020-01266-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529758/
https://www.ncbi.nlm.nih.gov/pubmed/33005001
http://dx.doi.org/10.1038/s42003-020-01266-9

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