The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells

Radiotherapy has a central role in the treatment of head and neck squamous cell carcinoma (HNSCC). Activation of the PI3K/AKT/mTOR pathway can decrease the efficiency of radiotherapy via the promotion of cell survival and DNA repair. Here, the influence of PI3K pathway inhibition on radiotherapy res...

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Autores principales: Glorieux, Mary, Dok, Rüveyda, Nuyts, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529775/
https://www.ncbi.nlm.nih.gov/pubmed/33004905
http://dx.doi.org/10.1038/s41598-020-73249-z
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author Glorieux, Mary
Dok, Rüveyda
Nuyts, Sandra
author_facet Glorieux, Mary
Dok, Rüveyda
Nuyts, Sandra
author_sort Glorieux, Mary
collection PubMed
description Radiotherapy has a central role in the treatment of head and neck squamous cell carcinoma (HNSCC). Activation of the PI3K/AKT/mTOR pathway can decrease the efficiency of radiotherapy via the promotion of cell survival and DNA repair. Here, the influence of PI3K pathway inhibition on radiotherapy response was investigated. Two PI3K inhibitors were investigated and both BKM120 and GDC0980 effectively inhibited cellular and clonogenic growth in 6 HNSCC cells, both HPV-positive as well as HPV-negative. Despite targeted inhibition of the pathway and slight increase in DNA damage, PI3K inhibition did not show significant radiosensitization. Currently only one clinical trial is assessing the effectiveness of combining BKM120 with RT in HNSCC (NCT02113878) of which the results are eagerly awaited.
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spelling pubmed-75297752020-10-02 The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells Glorieux, Mary Dok, Rüveyda Nuyts, Sandra Sci Rep Article Radiotherapy has a central role in the treatment of head and neck squamous cell carcinoma (HNSCC). Activation of the PI3K/AKT/mTOR pathway can decrease the efficiency of radiotherapy via the promotion of cell survival and DNA repair. Here, the influence of PI3K pathway inhibition on radiotherapy response was investigated. Two PI3K inhibitors were investigated and both BKM120 and GDC0980 effectively inhibited cellular and clonogenic growth in 6 HNSCC cells, both HPV-positive as well as HPV-negative. Despite targeted inhibition of the pathway and slight increase in DNA damage, PI3K inhibition did not show significant radiosensitization. Currently only one clinical trial is assessing the effectiveness of combining BKM120 with RT in HNSCC (NCT02113878) of which the results are eagerly awaited. Nature Publishing Group UK 2020-10-01 /pmc/articles/PMC7529775/ /pubmed/33004905 http://dx.doi.org/10.1038/s41598-020-73249-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Glorieux, Mary
Dok, Rüveyda
Nuyts, Sandra
The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells
title The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells
title_full The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells
title_fullStr The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells
title_full_unstemmed The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells
title_short The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells
title_sort influence of pi3k inhibition on the radiotherapy response of head and neck cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529775/
https://www.ncbi.nlm.nih.gov/pubmed/33004905
http://dx.doi.org/10.1038/s41598-020-73249-z
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