Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis

We analyzed 1196 proteins in longitudinal plasma samples from participants in a commercial wellness program, including samples collected pre-diagnosis from ten cancer patients and 69 controls. For three individuals ultimately diagnosed with metastatic breast, lung, or pancreatic cancer, CEACAM5 was...

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Autores principales: Magis, Andrew T., Rappaport, Noa, Conomos, Matthew P., Omenn, Gilbert S., Lovejoy, Jennifer C., Hood, Leroy, Price, Nathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529776/
https://www.ncbi.nlm.nih.gov/pubmed/33004987
http://dx.doi.org/10.1038/s41598-020-73451-z
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author Magis, Andrew T.
Rappaport, Noa
Conomos, Matthew P.
Omenn, Gilbert S.
Lovejoy, Jennifer C.
Hood, Leroy
Price, Nathan D.
author_facet Magis, Andrew T.
Rappaport, Noa
Conomos, Matthew P.
Omenn, Gilbert S.
Lovejoy, Jennifer C.
Hood, Leroy
Price, Nathan D.
author_sort Magis, Andrew T.
collection PubMed
description We analyzed 1196 proteins in longitudinal plasma samples from participants in a commercial wellness program, including samples collected pre-diagnosis from ten cancer patients and 69 controls. For three individuals ultimately diagnosed with metastatic breast, lung, or pancreatic cancer, CEACAM5 was a persistent longitudinal outlier as early as 26.5 months pre-diagnosis. CALCA, a biomarker for medullary thyroid cancer, was hypersecreted in metastatic pancreatic cancer at least 16.5 months pre-diagnosis. ERBB2 levels spiked in metastatic breast cancer between 10.0 and 4.0 months pre-diagnosis. Our results support the value of deep phenotyping seemingly healthy individuals in prospectively inferring disease transitions.
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spelling pubmed-75297762020-10-02 Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis Magis, Andrew T. Rappaport, Noa Conomos, Matthew P. Omenn, Gilbert S. Lovejoy, Jennifer C. Hood, Leroy Price, Nathan D. Sci Rep Article We analyzed 1196 proteins in longitudinal plasma samples from participants in a commercial wellness program, including samples collected pre-diagnosis from ten cancer patients and 69 controls. For three individuals ultimately diagnosed with metastatic breast, lung, or pancreatic cancer, CEACAM5 was a persistent longitudinal outlier as early as 26.5 months pre-diagnosis. CALCA, a biomarker for medullary thyroid cancer, was hypersecreted in metastatic pancreatic cancer at least 16.5 months pre-diagnosis. ERBB2 levels spiked in metastatic breast cancer between 10.0 and 4.0 months pre-diagnosis. Our results support the value of deep phenotyping seemingly healthy individuals in prospectively inferring disease transitions. Nature Publishing Group UK 2020-10-01 /pmc/articles/PMC7529776/ /pubmed/33004987 http://dx.doi.org/10.1038/s41598-020-73451-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Magis, Andrew T.
Rappaport, Noa
Conomos, Matthew P.
Omenn, Gilbert S.
Lovejoy, Jennifer C.
Hood, Leroy
Price, Nathan D.
Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis
title Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis
title_full Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis
title_fullStr Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis
title_full_unstemmed Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis
title_short Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis
title_sort untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529776/
https://www.ncbi.nlm.nih.gov/pubmed/33004987
http://dx.doi.org/10.1038/s41598-020-73451-z
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