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Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort

Ocular melanomas are uncommon cancers in Southeast Asia unlike in the West. We conducted a retrospective review of patients (n = 44) with histologically-proven ocular melanoma within a multi-ethnic Asian cohort from Singapore. Clinicopathological features and relapse patterns were examined, and surv...

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Autores principales: Tan, Laura Ling Ying, Hong, Jiancheng, Goh, Wei Lin, Chang, Esther Wei Yin, Yang, Valerie Shiwen, Poon, Eileen, Somasundaram, Nagavalli, Farid, Mohamad, Chan, Anita Sook Yee, Chan, Jason Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529790/
https://www.ncbi.nlm.nih.gov/pubmed/33004998
http://dx.doi.org/10.1038/s41598-020-73534-x
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author Tan, Laura Ling Ying
Hong, Jiancheng
Goh, Wei Lin
Chang, Esther Wei Yin
Yang, Valerie Shiwen
Poon, Eileen
Somasundaram, Nagavalli
Farid, Mohamad
Chan, Anita Sook Yee
Chan, Jason Yongsheng
author_facet Tan, Laura Ling Ying
Hong, Jiancheng
Goh, Wei Lin
Chang, Esther Wei Yin
Yang, Valerie Shiwen
Poon, Eileen
Somasundaram, Nagavalli
Farid, Mohamad
Chan, Anita Sook Yee
Chan, Jason Yongsheng
author_sort Tan, Laura Ling Ying
collection PubMed
description Ocular melanomas are uncommon cancers in Southeast Asia unlike in the West. We conducted a retrospective review of patients (n = 44) with histologically-proven ocular melanoma within a multi-ethnic Asian cohort from Singapore. Clinicopathological features and relapse patterns were examined, and survival outcomes of interest included recurrence-free survival (RFS) and overall survival (OS). Survival analysis was performed using the Kaplan–Meier method and multivariable Cox proportional regression. The study cohort included 18 male and 26 female patients, with a median age of 52 years (range 8–78). Median follow-up was 154 months. For uveal melanomas (n = 29), the 5-year RFS and OS was 56.8% and 76.6%, respectively; whilst for conjunctival melanomas (n = 15), the 5-year RFS and OS was 30.1% and 68.8%, respectively. Fifteen patients (38.5%) eventually developed metastasis, following which the median survival was only 17 months. Multivariate analysis demonstrated that higher T stage was a significant independent predictor for both OS (HR 8.69, 95% CI 1.03 to 73.09, p = 0.047) and RFS (HR 11.62, 95% CI 2.45 to 55.00, p = 0.002). Smoking history was independently predictive of better RFS (HR 0.08, 95% CI 0.01 to 0.78, p = 0.030). In conclusion, our study demonstrates the poor ocular melanoma outcomes in Southeast Asians, highlighting the necessity for urgent research in this area of unmet clinical need.
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spelling pubmed-75297902020-10-02 Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort Tan, Laura Ling Ying Hong, Jiancheng Goh, Wei Lin Chang, Esther Wei Yin Yang, Valerie Shiwen Poon, Eileen Somasundaram, Nagavalli Farid, Mohamad Chan, Anita Sook Yee Chan, Jason Yongsheng Sci Rep Article Ocular melanomas are uncommon cancers in Southeast Asia unlike in the West. We conducted a retrospective review of patients (n = 44) with histologically-proven ocular melanoma within a multi-ethnic Asian cohort from Singapore. Clinicopathological features and relapse patterns were examined, and survival outcomes of interest included recurrence-free survival (RFS) and overall survival (OS). Survival analysis was performed using the Kaplan–Meier method and multivariable Cox proportional regression. The study cohort included 18 male and 26 female patients, with a median age of 52 years (range 8–78). Median follow-up was 154 months. For uveal melanomas (n = 29), the 5-year RFS and OS was 56.8% and 76.6%, respectively; whilst for conjunctival melanomas (n = 15), the 5-year RFS and OS was 30.1% and 68.8%, respectively. Fifteen patients (38.5%) eventually developed metastasis, following which the median survival was only 17 months. Multivariate analysis demonstrated that higher T stage was a significant independent predictor for both OS (HR 8.69, 95% CI 1.03 to 73.09, p = 0.047) and RFS (HR 11.62, 95% CI 2.45 to 55.00, p = 0.002). Smoking history was independently predictive of better RFS (HR 0.08, 95% CI 0.01 to 0.78, p = 0.030). In conclusion, our study demonstrates the poor ocular melanoma outcomes in Southeast Asians, highlighting the necessity for urgent research in this area of unmet clinical need. Nature Publishing Group UK 2020-10-01 /pmc/articles/PMC7529790/ /pubmed/33004998 http://dx.doi.org/10.1038/s41598-020-73534-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tan, Laura Ling Ying
Hong, Jiancheng
Goh, Wei Lin
Chang, Esther Wei Yin
Yang, Valerie Shiwen
Poon, Eileen
Somasundaram, Nagavalli
Farid, Mohamad
Chan, Anita Sook Yee
Chan, Jason Yongsheng
Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort
title Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort
title_full Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort
title_fullStr Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort
title_full_unstemmed Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort
title_short Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort
title_sort clinical features and survival outcomes of ocular melanoma in a multi-ethnic asian cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529790/
https://www.ncbi.nlm.nih.gov/pubmed/33004998
http://dx.doi.org/10.1038/s41598-020-73534-x
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