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Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
DNA strand breaks recruit PARP1 and its paralogue PARP2 to modify histones and many other substrates with mono- and poly(ADP-ribose) (PAR)(1–5). In DNA damage response, the PAR post-translational modification occurs predominantly on serine amino acids(6–8), which requires HPF1, an accessory factor t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529888/ https://www.ncbi.nlm.nih.gov/pubmed/32939087 http://dx.doi.org/10.1038/s41586-020-2725-7 |