PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth

Reprograming of proline metabolism is critical for tumor growth. Here we show that PINCH-1 is highly expressed in lung adenocarcinoma and promotes proline synthesis through regulation of mitochondrial dynamics. Knockout (KO) of PINCH-1 increases dynamin-related protein 1 (DRP1) expression and mitoch...

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Detalles Bibliográficos
Autores principales: Guo, Ling, Cui, Chunhong, Wang, Jiaxin, Yuan, Jifan, Yang, Qingyang, Zhang, Ping, Su, Wen, Bao, Ruolu, Ran, Jingchao, Wu, Chuanyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529891/
https://www.ncbi.nlm.nih.gov/pubmed/33004813
http://dx.doi.org/10.1038/s41467-020-18753-6

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