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Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
Testis-restricted melanoma antigen (MAGE) proteins are frequently hijacked in cancer and play a critical role in tumorigenesis. MAGEs assemble with E3 ubiquitin ligases and function as substrate adaptors that direct the ubiquitination of novel targets, including key tumor suppressors. However, how M...
Autores principales: | Yang, Seung Wook, Huang, Xin, Lin, Wenwei, Min, Jaeki, Miller, Darcie J., Mayasundari, Anand, Rodrigues, Patrick, Griffith, Elizabeth C., Gee, Clifford T., Li, Lei, Li, Wei, Lee, Richard E., Rankovic, Zoran, Chen, Taosheng, Potts, Patrick Ryan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529893/ https://www.ncbi.nlm.nih.gov/pubmed/33004795 http://dx.doi.org/10.1038/s41467-020-18708-x |
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