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A rare case of cavernous hemangioma accompanied with diffuse hepatic hemangiomatosis

BACKGROUND: Hepatic cavernous hemangioma (CH) is the most common hepatic benign tumor. Most cases are solitary, asymptomatic, and found incidentally. In symptomatic cases with rapidly growing tumors and coagulopathy, surgical treatment is considered. In rare cases, diffuse hepatic hemangiomatosis (D...

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Autores principales: Ota, Takuji, Kamiyama, Toshiya, Kato, Takuya, Hanamoto, Takayuki, Hirose, Kunihiro, Otsuka, Noriyuki, Matsuoka, Shinichi, Taketomi, Akinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530161/
https://www.ncbi.nlm.nih.gov/pubmed/33001265
http://dx.doi.org/10.1186/s40792-020-01023-4
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author Ota, Takuji
Kamiyama, Toshiya
Kato, Takuya
Hanamoto, Takayuki
Hirose, Kunihiro
Otsuka, Noriyuki
Matsuoka, Shinichi
Taketomi, Akinobu
author_facet Ota, Takuji
Kamiyama, Toshiya
Kato, Takuya
Hanamoto, Takayuki
Hirose, Kunihiro
Otsuka, Noriyuki
Matsuoka, Shinichi
Taketomi, Akinobu
author_sort Ota, Takuji
collection PubMed
description BACKGROUND: Hepatic cavernous hemangioma (CH) is the most common hepatic benign tumor. Most cases are solitary, asymptomatic, and found incidentally. In symptomatic cases with rapidly growing tumors and coagulopathy, surgical treatment is considered. In rare cases, diffuse hepatic hemangiomatosis (DHH) is reported as a comorbidity. The etiology of DHH is unknown. CASE PRESENTATION: A 29-year-old female patient had a history of endometriosis treated with oral contraceptives. Hepatic CH was incidentally detected in the segment IVa of the liver according to the Couinaud classification. Follow-up computed tomography (CT) and ultrasound sonography showed the growth of the lesion and formation of multiple new lesions near the first. Enhanced CT and magnetic resonance imaging (MRI) revealed that the new lesions were different from CH. Although oral contraceptives were stopped, all lesions grew in size. Malignancy and possibility of rupture of these tumors were considered due to the clinical course, and we opted for surgical removal of the tumors. Left liver lobectomy and cholecystectomy were performed. Surgical findings were small red spot spreading and a mass in segment IV of the liver. Pathological examination revealed a circumscribed sponge-like tumor with diffuse irregular extension to the adjacent area. Both of the lesions consisted of blood-filled dilated vascular spaces lined by flat endothelium without atypia. The diagnosis was hepatic CH with DHH. The patient was discharged on postoperative day 12 uneventfully. CONCLUSION: We report the successful resection of CH with DHH. The case findings suggest a relationship between oral contraceptive use and enlargement of CH and DHH. Although DHH has been poorly understood, a few previously published cases reported DHH occurrence in patients using oral contraceptives. In such cases, the decision to perform surgical resection should be made after careful examination.
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spelling pubmed-75301612020-10-19 A rare case of cavernous hemangioma accompanied with diffuse hepatic hemangiomatosis Ota, Takuji Kamiyama, Toshiya Kato, Takuya Hanamoto, Takayuki Hirose, Kunihiro Otsuka, Noriyuki Matsuoka, Shinichi Taketomi, Akinobu Surg Case Rep Case Report BACKGROUND: Hepatic cavernous hemangioma (CH) is the most common hepatic benign tumor. Most cases are solitary, asymptomatic, and found incidentally. In symptomatic cases with rapidly growing tumors and coagulopathy, surgical treatment is considered. In rare cases, diffuse hepatic hemangiomatosis (DHH) is reported as a comorbidity. The etiology of DHH is unknown. CASE PRESENTATION: A 29-year-old female patient had a history of endometriosis treated with oral contraceptives. Hepatic CH was incidentally detected in the segment IVa of the liver according to the Couinaud classification. Follow-up computed tomography (CT) and ultrasound sonography showed the growth of the lesion and formation of multiple new lesions near the first. Enhanced CT and magnetic resonance imaging (MRI) revealed that the new lesions were different from CH. Although oral contraceptives were stopped, all lesions grew in size. Malignancy and possibility of rupture of these tumors were considered due to the clinical course, and we opted for surgical removal of the tumors. Left liver lobectomy and cholecystectomy were performed. Surgical findings were small red spot spreading and a mass in segment IV of the liver. Pathological examination revealed a circumscribed sponge-like tumor with diffuse irregular extension to the adjacent area. Both of the lesions consisted of blood-filled dilated vascular spaces lined by flat endothelium without atypia. The diagnosis was hepatic CH with DHH. The patient was discharged on postoperative day 12 uneventfully. CONCLUSION: We report the successful resection of CH with DHH. The case findings suggest a relationship between oral contraceptive use and enlargement of CH and DHH. Although DHH has been poorly understood, a few previously published cases reported DHH occurrence in patients using oral contraceptives. In such cases, the decision to perform surgical resection should be made after careful examination. Springer Berlin Heidelberg 2020-10-01 /pmc/articles/PMC7530161/ /pubmed/33001265 http://dx.doi.org/10.1186/s40792-020-01023-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Ota, Takuji
Kamiyama, Toshiya
Kato, Takuya
Hanamoto, Takayuki
Hirose, Kunihiro
Otsuka, Noriyuki
Matsuoka, Shinichi
Taketomi, Akinobu
A rare case of cavernous hemangioma accompanied with diffuse hepatic hemangiomatosis
title A rare case of cavernous hemangioma accompanied with diffuse hepatic hemangiomatosis
title_full A rare case of cavernous hemangioma accompanied with diffuse hepatic hemangiomatosis
title_fullStr A rare case of cavernous hemangioma accompanied with diffuse hepatic hemangiomatosis
title_full_unstemmed A rare case of cavernous hemangioma accompanied with diffuse hepatic hemangiomatosis
title_short A rare case of cavernous hemangioma accompanied with diffuse hepatic hemangiomatosis
title_sort rare case of cavernous hemangioma accompanied with diffuse hepatic hemangiomatosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530161/
https://www.ncbi.nlm.nih.gov/pubmed/33001265
http://dx.doi.org/10.1186/s40792-020-01023-4
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