Case Report: Safety and Efficacy of Denosumab in Four Children With Noonan Syndrome With Multiple Giant Cell Lesions of the Jaw

Noonan syndrome is a genetic disorder caused by mutations in the RAS/MAPK pathway. Multiple giant cell lesions are a rare sequelae of disruptions in this pathway, termed Noonan-like multiple giant cell lesions (NL/MGCLs). Medical management of these tumors rather than surgical intervention is prefer...

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Detalles Bibliográficos
Autores principales: Ferriero, Kristen, Shah, Biraj, Yan, Yun, Khatri, Surya, Caccamese, John, Napoli, Joseph A., Bober, Michael B., Crane, Janet L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530181/
https://www.ncbi.nlm.nih.gov/pubmed/33042901
http://dx.doi.org/10.3389/fped.2020.00515

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