Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

Numerous pathological conditions, including cancer, inflammatory diseases, and neurodegenerative diseases, are accompanied by overproduction of reactive oxygen species (ROS). This makes ROS vital flagging molecules in disease pathology. ROS-responsive drug delivery platforms have been developed. Nan...

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Autores principales: Liu, Jinggong, Li, Yongjin, Chen, Song, Lin, Yongpeng, Lai, Haoqiang, Chen, Bolai, Chen, Tianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530259/
https://www.ncbi.nlm.nih.gov/pubmed/33062637
http://dx.doi.org/10.3389/fchem.2020.00838
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author Liu, Jinggong
Li, Yongjin
Chen, Song
Lin, Yongpeng
Lai, Haoqiang
Chen, Bolai
Chen, Tianfeng
author_facet Liu, Jinggong
Li, Yongjin
Chen, Song
Lin, Yongpeng
Lai, Haoqiang
Chen, Bolai
Chen, Tianfeng
author_sort Liu, Jinggong
collection PubMed
description Numerous pathological conditions, including cancer, inflammatory diseases, and neurodegenerative diseases, are accompanied by overproduction of reactive oxygen species (ROS). This makes ROS vital flagging molecules in disease pathology. ROS-responsive drug delivery platforms have been developed. Nanotechnology has been broadly applied in the field of biomedicine leading to the progress of ROS-responsive nanoparticles. In this review, we focused on the production and physiological/pathophysiological impact of ROS. Particular emphasis is put on the mechanisms and effects of abnormal ROS levels on oxidative stress diseases, including cancer, inflammatory disease, and neurodegenerative diseases. Finally, we summarized the potential biomedical applications of ROS-responsive nanocarriers in these oxidative stress diseases. We provide insights that will help in the designing of new ROS-responsive nanocarriers for various applications.
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spelling pubmed-75302592020-10-13 Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases Liu, Jinggong Li, Yongjin Chen, Song Lin, Yongpeng Lai, Haoqiang Chen, Bolai Chen, Tianfeng Front Chem Chemistry Numerous pathological conditions, including cancer, inflammatory diseases, and neurodegenerative diseases, are accompanied by overproduction of reactive oxygen species (ROS). This makes ROS vital flagging molecules in disease pathology. ROS-responsive drug delivery platforms have been developed. Nanotechnology has been broadly applied in the field of biomedicine leading to the progress of ROS-responsive nanoparticles. In this review, we focused on the production and physiological/pathophysiological impact of ROS. Particular emphasis is put on the mechanisms and effects of abnormal ROS levels on oxidative stress diseases, including cancer, inflammatory disease, and neurodegenerative diseases. Finally, we summarized the potential biomedical applications of ROS-responsive nanocarriers in these oxidative stress diseases. We provide insights that will help in the designing of new ROS-responsive nanocarriers for various applications. Frontiers Media S.A. 2020-09-18 /pmc/articles/PMC7530259/ /pubmed/33062637 http://dx.doi.org/10.3389/fchem.2020.00838 Text en Copyright © 2020 Liu, Li, Chen, Lin, Lai, Chen and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Liu, Jinggong
Li, Yongjin
Chen, Song
Lin, Yongpeng
Lai, Haoqiang
Chen, Bolai
Chen, Tianfeng
Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases
title Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases
title_full Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases
title_fullStr Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases
title_full_unstemmed Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases
title_short Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases
title_sort biomedical application of reactive oxygen species–responsive nanocarriers in cancer, inflammation, and neurodegenerative diseases
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530259/
https://www.ncbi.nlm.nih.gov/pubmed/33062637
http://dx.doi.org/10.3389/fchem.2020.00838
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