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PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia
The immune checkpoint inhibitor programmed cell death protein 1 (PD-1) plays a critical role in immune regulation. Recent studies have demonstrated functional PD-1 expression in peripheral sensory neurons, which contributes to neuronal excitability, pain, and opioid analgesia. Here we report neurona...
Autores principales: | Jiang, Changyu, Wang, Zilong, Donnelly, Christopher R., Wang, Kaiyuan, Andriessen, Amanda S., Tao, Xueshu, Matsuda, Megumi, Zhao, Junli, Ji, Ru-Rong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530307/ https://www.ncbi.nlm.nih.gov/pubmed/33083737 http://dx.doi.org/10.1016/j.isci.2020.101570 |
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