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Regulation, diversity and function of MECP2 exon and 3′UTR isoforms

The methyl-CpG-binding protein 2 (MECP2) is a critical global regulator of gene expression. Mutations in MECP2 cause neurodevelopmental disorders including Rett syndrome (RTT). MECP2 exon 2 is spliced into two alternative messenger ribonucleic acid (mRNA) isoforms encoding MECP2-E1 or MECP2-E2 prote...

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Detalles Bibliográficos
Autores principales:	Rodrigues, Deivid Carvalho, Mufteev, Marat, Ellis, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Invited Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530521/ https://www.ncbi.nlm.nih.gov/pubmed/32681172 http://dx.doi.org/10.1093/hmg/ddaa154

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